教授·博士生导师·广东工业大学生物医药学院副院长（百人特聘教授）
邮箱：jinxingye@gdut.edu.cn 1584090107@qq.com 地址：广州市番禺区广州大学城外环西路100号，广东工业大学生物医药学院，510006
叶金星，教授、博士生导师，现任广东工业大学生物医药学院副院长（百人特聘教授）。2007—2021年任职于华东理工大学药学院，先后任副研究员、教授、院长助理、副院长，并担任制药工程与过程化学教育部工程研究中心主任助理、主任。入选上海市“浦江人才计划”、教育部“新世纪优秀人才支持计划”、江苏省“双创人才计划”、广东省“珠江人才计划”领军人才，获英国皇家学会博士后奖学金及Thieme Chemistry Journal Award。先后在英国曼彻斯特大学（D. Dixon 教授）、日本名古屋大学（诺贝尔化学奖得主野依良治教授）从事博士后研究，并赴美国加州大学伯克利分校任访问学者。
研究以不对称催化方法学立学，逐步形成“方法学—工艺—装备—智能化”的全链条能力：2015年起在国内较早开展药物连续流动制造研究，主持两项上海市重大专项原型机子课题，研制出药物自动合成仪（模块化连续流合成平台）及系列连续流反应—纯化装备；2024 年起布局“AI+新药创制”与“AI+合成生物学”，开展杀虫剂、抗菌剂、功效化妆品原料的设计，光酶、糖基化酶、聚氨酯水解酶等的从头设计与功能蛋白 AI 设计；2026 年起新增“核酸药物化学与高端药用辅料”方向，围绕脂质纳米粒（LNP）关键辅料开展可降解可电离脂质、肝靶向替代配体与辅助脂质的设计与制造研究。
主持国家自然科学基金 5 项、省部级及企业课题 30 余项，申请专利 50 余项、授权 24 项；与美国礼来（Eli Lilly）、上海医药集团、润丰化工、同成医药、广州伽能、广东宇通、广东银美、广东莱恩等企业建立联合研究中心或合作攻关，绿色连续工艺支撑索非布韦等品种产业化（江苏省科学技术奖）。
连续流动合成与智能装备
以过程强化（Process Intensification）与连续制造（Continuous Manufacturing）为主线，针对药物合成“反应慢、放热强、中间体危险、放大失真”四类共性难题，构建“微反应器—连续合成—在线纯化—自动控制”一体化装备与工艺体系。已在心血管药、农药及精细化学品上完成放大验证，正向多肽 / PDC、寡核苷酸等延伸。
药物化学与绿色制药工艺
面向医药、农药及高端化学品的实用合成与制造：发展合成方法、不对称催化、Ir/PNN均相不对称氢化、非均相催化与酶催化，并以连续制造理念重构传统釜式工艺；相关成果支撑索非布韦、瑞舒伐他汀等品种/中间体的绿色产业化。
AI + 合成生物学（在研）
2024 年起布局：以蛋白语言模型、结构预测与生成式设计为核心，开展蛋白质 / 酶的 AI 挖掘、从头设计与定向进化；聚焦光酶、聚氨酯水解酶、糖基转移酶等生物催化体系，并与蛋白表达、效能评价、优化方法等衔接，形成“设计—构建—测试—学习”（DBTL）闭环体系。
AI + 药物化学（在研）
以人工智能辅助药物设计为基础，结合贝叶斯优化、主动学习与机器学习势函数开展分子库构建、药物活性筛选 / 药物优化、可合成性筛选与预测、反应性预测、合成 / 工艺条件优化等；努力建设可与流动化学装备直连的自主实验站（Self-driving Lab）。
功能生物分子创制与偶联递送化学
以“靶向模块—可切割连接子—载荷”的偶联范式为通用方法论，面向多肽 / PDC、寡核苷酸 / LNP、多糖三类功能生物分子，开展新骨架创制、偶联化学与精准递送研究；并与连续流动合成装备、AI 新分子骨架、新功能、新活性、新反应性预测双向衔接，努力形成“分子设计—连续制造—递送评价”的一体化能力。
有机催化与不对称合成
以手性胺的多功能协同活化立学，发展双功能与多功能有机催化体系，实现手性季碳、螺环与连续手性中心的高选择性构筑（vinylogous Michael、环加成、串联 / 级联）。催化剂、方法已被同行广泛采用，并与牛津大学 D. Dixon 教授长期合作；近年向手性配体—金属协同催化延展。
光电催化合成
面向绿色化学与“双碳”目标，发展以电子、光子替代化学计量氧化剂 / 还原剂的合成方法：汇聚成对电解、电化学 C–H 官能化、可见光氧化还原催化与光 / 铜协同催化，在温和条件下实现高原子经济性、低 E 因子的 C–H 与 C–X 键转化，为药物后期修饰提供新工具。
以下为团队正在推进、尚未见刊或以平台能力形式建设的方向，涵盖酶与功能蛋白的AI从头设计、新模态药物的连续合成—纯化与装备、核酸药物化学与高端药用辅料与自主实验站等。欢迎有意向的企业与同行来函探讨联合攻关。
酶与功能蛋白的AI从头设计
光酶（FMN 依赖）等催化酶与功能蛋白的 AI 挖掘、从头设计与改造；相关稿件处于同行评议阶段。（研究中）
新模态药物的自动化连续合成—纯化
面向多肽及 PDC、寡核苷酸等新模态药物，发展固相 / 液相合成与偶联的自动化连续流工艺与装备，解决批次间一致性与放大瓶颈。（建设中）
核酸药物化学与高端药用辅料
面向小核酸（siRNA / mRNA / ASO）药物递送与产业化的关键瓶颈，围绕脂质纳米粒（LNP）的核心辅料，开展“分子设计—合成工艺—质量控制”贯通研究，并结合流动化学装备发展连续流合成与纯化工艺。（建设中）
自主实验站（Self-driving Lab）
把自动合成 / 生物反应装备与 AI 大模型、机器人和闭环实验设计结合，实现“设计—制造—检测—优化”的无人化闭环。（长期目标）
编号前缀为方向代码（F＝连续流动合成、M＝药物化学与绿色制药工艺、B＝AI+合成生物学、C＝AI+药物化学、N＝功能生物分子、A＝有机催化、E＝光电催化）。
F1. Maolin Sun, Rixin Shao, Haoxiang Chen, Tianmin Guo, Hualiang Chen, Wuqiang Song, Chaoming Liang, Ruihua Cheng*, Tao Li*, Jinxing Ye*. Continuous flow modular synthetic platform for accelerated drug discovery. Eur. J. Med. Chem. 2026, 315, 118934. DOI: 10.1016/j.ejmech.2026.118934
F2. Liming Cao, Maolin Sun*, Chaoming Liang, Lei Yang, Yueyue Ma, Ruihua Cheng, Yanxiong Ke*, Wei Yu, Jinxing Ye*. A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate. Chin. Chem. Lett. 2024, 35(2), 108758. DOI: 10.1016/j.cclet.2023.108758
F3. Maolin Sun, Chaoming Liang, Liming Cao, Yaguo Wang, Jiasheng Yang, Shiyu Hou, Wei Yu, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*. Two-step continuous flow process of sodium tanshinone IIA sulfonate using a 3D circular cyclone-type microreactor. Chin. Chem. Lett. 2024, 35(1), 108738. DOI: 10.1016/j.cclet.2023.108738
F4. Shiyu Hou, Maolin Sun, Liming Cao, Chaoming Liang, Jiaxin Yang, Xinggui Zhou, Jinxing Ye*, Ruihua Cheng*. Computational fluid dynamics simulation and experimental study on mixing performance of a three-dimensional circular cyclone-type microreactor. Chin. Chem. Lett. 2024, 35(4), 108761. DOI: 10.1016/j.cclet.2023.108761
F5. Maolin Sun, Hong Li, Hualiang Chen, Rixin Shao, Fanghua Chen, Xiangmin Sang, Weixia Lin, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*. Efficient “One-Column” Grignard generation and reaction in continuous flow. J. Flow Chem. 2024, 14(4), 623-630. DOI: 10.1007/s41981-024-00332-1
F6. Weixia Lin, Zilong Lin, Chaoming Liang, Maolin Sun, Ruihua Cheng*, Jinxing Ye*. Rapid and practical synthesis of N-protected amino ketones in continuous flow via pre-deprotonation protocol. J. Flow Chem. 2024, 14(4), 631-639. DOI: 10.1007/s41981-024-00336-x
F7. Chao Shan, Jinping Xu, Liming Cao, Caoming Liang, Ruihua Cheng, Xiantong Yao, Maolin Sun*, Jinxing Ye*. Rapid synthesis of α-chiral piperidines via a highly diastereoselective continuous flow protocol. Org. Lett. 2022, 24, 3205-3210. DOI: 10.1021/acs.orglett.2c00975
F8. Chao Shan, Liming Cao, Lei Yang, Ruihua Cheng, Xiantong Yao, Caoming Liang, Maolin Sun*, Jinxing Ye*. Construction of an alpha-chiral pyrrolidine library with a rapid and scalable continuous flow protocol. React. Chem. Eng. 2022, 7, 1779-1785. DOI: 10.1039/d2re00145d
F9. Maolin Sun, Chaoming Liang, Xinyuan Shen, Jianchang Li, Ruihua Cheng, Jinxing Ye*. Continuous flow science in an undergraduate teaching laboratory: synthesis of ethylene glycol diacetate using heterogeneous catalysts in continuous flow. J. Chem. Educ. 2021, 98, 572-576. DOI: 10.1021/acs.jchemed.0c01226
F10. Maolin Sun, Jingxin Yang, Youtian Fu, Chaoming Liang, Hong Li, Guoming Yan, Chao Yin, Wei Yu, Yueyue Ma*, Ruihua Cheng*, and Jinxing Ye*. Continuous flow process for the synthesis of betahistine via aza-Michael-type reaction in water. Org. Process Res. Dev. 2021, 25, 1160-1166. DOI: 10.1021/acs.oprd.0c00543
F11. Maolin Sun, Jianchang Li, Chaoming Liang, Chao Shan, Xinyuan Shen, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*. Practical and rapid construction of 2-pyridyl ketone library in continuous flow. J. Flow Chem. 2020, 11, 91-98. DOI: 10.1007/s41981-020-00120-7
M1. Maolin Sun, Rixin Shao, Haoxiang Chen, Tianmin Guo, Hualiang Chen, Wuqiang Song, Chaoming Liang, Ruihua Cheng*, Tao Li*, Jinxing Ye*. Continuous flow modular synthetic platform for accelerated drug discovery. Eur. J. Med. Chem. 2026, 315, 118934. DOI: 10.1016/j.ejmech.2026.118934
M2. Xiantong Yao, Ruiyuan Peng, Xin Yang, Jinheng Zheng, Weijun Zhong, Qinghua Zhong, Zhengjie Wang, Dali Yang, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*. Visible-light-promoted copper-catalyzed etherification of aryl bromides via energy transfer. Org. Lett. 2025, 27, 7313-7318. DOI: 10.1021/acs.orglett.5c01919
M3. Maolin Sun, Hong Li, Hualiang Chen, Rixin Shao, Fanghua Chen, Xiangmin Sang, Weixia Lin, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*. Efficient “One-Column” Grignard generation and reaction in continuous flow. J. Flow Chem. 2024, 14(4), 623-630. DOI: 10.1007/s41981-024-00332-1
M4. Weixia Lin, Zilong Lin, Chaoming Liang, Maolin Sun, Ruihua Cheng*, Jinxing Ye*. Rapid and practical synthesis of N-protected amino ketones in continuous flow via pre-deprotonation protocol. J. Flow Chem. 2024, 14(4), 631-639. DOI: 10.1007/s41981-024-00336-x
M5. Ling Zhang, Youtian Fu, Lei Yang, Liming Cao, Junjun Yi, Maolin Sun, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*. Direct electrochemical synthesis of quinones from simple aromatics and heteroaromatics. Chem. Commun. 2023, 59(47), 7255-7258. DOI: 10.1039/d3cc01661g
M6. Lei Zhang, Liming Cao, Maolin Sun, Chaoming Liang, Lei Yang, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*. One-pot synthesis of chiral 1-aryl-2-aminoethanols via Ir-catalyzed asymmetric hydrogenation. Chem. Eur. J. 2023, 29(29), e202300367. DOI: 10.1002/chem.202300367
M7. Lei Zhang, Chengyu Liu, Maolin Sun, Chaoming Liang, Liming Cao, Xiantong Yao, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*. Iridium-catalyzed asymmetric hydrogenation of simple ketones with tridentate PNN ligands bearing unsymmetrical vicinal diamines. J. Org. Chem. 2023, 88(5), 2942-2951. DOI: 10.1021/acs.joc.2c02676
M8. Huan Dong, Zhiheng Feng, Maolin Sun, Shihao Zhu, Jinghong Zhou, Wei Li, Jinxing Ye, Ruihua Cheng,. A wide range of poly(glycolic acid)-based di- and tri-block polyesters by a single organocatalyst: Synthesis and characterization. J. Polym. Sci. 2023. DOI: 10.1002/pol.20230231
M9. Yan Xiong, Chengyu Liu, Lei Zhang, Xin Wang, Jiaxin Yang, Zhen Liu, Jinxing Ye*, Ruihua Cheng*. Theoretical exploration of mechanism and ligand effects of asymmetric hydrogenation of β-amino ketone catalyzed by an iridium-PNN catalyst. Organometallics 2023, 42(9), 757-768. DOI: 10.1021/acs.organomet.2c00327
M10. Hongwei Zhang, Ying Liu, Ling Zhang, Xiong Wang, He Sun, Chengyu Liu, Jinxing Ye, Ruihua Cheng*. Direct reductive amination from ketones, aldehydes to synthesize amines using N, S-dual doped Co/C catalyst. Catal. Lett. 2022. DOI: 10.1007/s10562-021-03911-2
M11. Lei Yang, Maolin Sun, Liming Cao, Chaoming Liang, Jiasheng Yang, Junjun Yi, Ruihua Cheng, Yueyue Ma*, and Jinxing Ye*. Electricity-driven three-component reductive coupling reaction for the synthesis of diarylmethylamine. Chem. Commun. 2022, 58, 13345-13348. DOI: 10.1039/d2cc05330f
M12. Yutao Tong, Ruihua Cheng*, Huan Dong, Zhen Liu, Jinxing Ye, Boping Liu*. Highly active bifunctional dual-arm organoboron catalysts bearing cooperative intramolecular structures for the copolymerization of CO2 and epoxides. J. CO2 Util. 2022, 60, 101979. DOI: 10.1016/j.jcou.2022.101979
M13. Pufan Ni, Lei Yang, Yi Shen, Lei Zhang, Yueyue Ma, Maolin Sun, Ruihua Cheng*, and Jinxing Ye*. Synthesis of phenols from aryl ammonium salts under mild conditions. J. Org. Chem. 2022, 87, 12677-12687. DOI: 10.1021/acs.joc.2c01133
M14. Jingyi Wang, Chengyu Liu, Liming Cao, Yan Xiong, Jinxing Ye*, Zhen Liu*, Ruihua Cheng*. Theoretical investigation of mechanism and ligand effects on half-sandwich iridium complexes for direct reductive amination. Mol. Catal. 2022, 517, 112050. DOI: 10.1016/j.mcat.2021.112050
M15. Ling Zhang, Youtian Fu, Yi Shen, Chengyu Liu, Maolin Sun, Ruihua Cheng, Weiping Zhu, Xuhong Qian, Yueyue Ma*, Jinxing Ye*. Ritter-type amination of C(sp(3))-H bonds enabled by electrochemistry with SO42-. Nat. Commun. 2022, 13. DOI: 10.1038/s41467-022-31813-3
M16. Chao Shan, Jinping Xu, Liming Cao, Caoming Liang, Ruihua Cheng, Xiantong Yao, Maolin Sun*, Jinxing Ye*. Rapid synthesis of α-chiral piperidines via a highly diastereoselective continuous flow protocol. Org. Lett. 2022, 24, 3205-3210. DOI: 10.1021/acs.orglett.2c00975
M17. Chao Shan, Liming Cao, Lei Yang, Ruihua Cheng, Xiantong Yao, Caoming Liang, Maolin Sun*, Jinxing Ye*. Construction of an alpha-chiral pyrrolidine library with a rapid and scalable continuous flow protocol. React. Chem. Eng. 2022, 7, 1779-1785. DOI: 10.1039/d2re00145d
M18. Yueyue Ma, Jufei Hong, Xiantong Yao, Chengyu Liu, Ling Zhang, Youtian Fu, Maolin Sun, Ruihua Cheng, Zhong Li*, Jinxing Ye*. Aminomethylation of aryl bromides by nickel-catalyzed electrochemical redox neutral cross coupling. Org. Lett. 2021, 23, 9387-9392. DOI: 10.1021/acs.orglett.1c03500
M19. Maolin Sun, Jingxin Yang, Youtian Fu, Chaoming Liang, Hong Li, Guoming Yan, Chao Yin, Wei Yu, Yueyue Ma*, Ruihua Cheng*, and Jinxing Ye*. Continuous flow process for the synthesis of betahistine via aza-Michael-type reaction in water. Org. Process Res. Dev. 2021, 25, 1160-1166. DOI: 10.1021/acs.oprd.0c00543
M20. Chaoming Liang, Maolin Sun, Xinyuan Shen, Chao Shan, Weijuan Wang, Ruihua Cheng, and Jinxing Ye*. Three-step one-pot process of 3-methyl-5-benzofuranol from amine, aldehydes, and p-benzoquinone. Org. Process Res. Dev. 2021, 25, 810-816. DOI: 10.1021/acs.oprd.0c00507
M21. Li Wu, Wei Liu, Jinxing Ye, Ruihua Cheng*. Fast cyclotrimerization of a wide range of isocyanates to isocyanurates over acid/base conjugates under bulk conditions. Cat. Commun. 2020, 145, 106097. DOI: 10.1016/j.catcom.2020.106097
M22. Maolin Sun, Jianchang Li, Chaoming Liang, Chao Shan, Xinyuan Shen, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*. Practical and rapid construction of 2-pyridyl ketone library in continuous flow. J. Flow Chem. 2020, 11, 91-98. DOI: 10.1007/s41981-020-00120-7
M23. Yueyue Ma, Xiantong Yao, Lei Zhang, Pufan Ni, Ruihua Cheng, Jinxing Ye*. Direct arylation of α-amino C(sp3)-H bonds by convergent paired electrolysis. Angew. Chem. Int. Ed. 2019, 58(46), 16548-16552. DOI: 10.1002/anie.201909642
M24. Yueyue Ma, Jufeng Lv, Chengyu Liu, Xiantong Yao, Guoming Yan, Wei Yu, Jinxing Ye*. Electrochemical [4+2] annulation-rearrangement-aromatization of styrenes: synthesis of naphthalene derivatives. Angew. Chem. Int. Ed. 2019, 58(20), 6756-6760. DOI: 10.1002/anie.201902315
M25. Jun Xu*, Yifei Michelle Liu, Andrew S. Lipton, Jinxing Ye, Gina L. Hoatson, Phillip J. Milner, Thomas M. McDonald, Rebecca L. Siegelman, Alexander C. Forse, Berend Smit, Jeffrey R. Long*, Jeffrey A. Reimer*. Amine dynamics in diamine-appended Mg2(dobpdc) metal-organic frameworks. J. Phys. Chem. Lett. 2019, 10(22), 7044-7049. DOI: 10.1021/acs.jpclett.9b02883
M26. Shupeng Dong, Guibing Wu, Xiaoqian Yuan, Chuncheng Zou, Jinxing Ye*. Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source. Org. Chem. Front. 2017, 4, 2230-2234. DOI: 10.1039/c7qo00453b
M27. Mercedes K. Taylor, Tomče Runčevski, Julia Oktawiec, Miguel I. Gonzalez, Rebecca L. Siegelman, Jarad A. Mason, Jinxing Ye, Craig M. Brown, Jeffrey R. Long*. Tuning the adsorption-induced phase change in the flexible metal–organic framework Co(bdp). J. Am. Chem. Soc. 2016, 138, 15019-15026. DOI: 10.1021/jacs.6b09155
M28. Fei Wang, Na Zhu, Pinhong Chen, Jinxing Ye, Guosheng Liu*. Copper-catalyzed trifluoromethylazidation of alkynes: efficient access to CF3-substituted azirines and aziridines. Angew. Chem. Int. Ed. 2015, 54, 9356-9360. DOI: 10.1002/anie.201503412
M29. Na Zhu, Fei Wang, Pinhong Chen, Jinxing Ye*, Guosheng Liu*. Copper-catalyzed intermolecular trifluoromethylazidation and trifluoromethylthiocyanation of allenes: efficient access to CF3-containing allyl azides and thiocyanates. Org. Lett. 2015, 17, 3580-3583. DOI: 10.1021/acs.orglett.5b01677
M30. Jiabin Xu, Xin Mu, Pinhong Chen, Jinxing Ye*, and Guosheng Liu*. Copper-catalyzed trifluoromethylthiolation of aryl halides with diverse directing groups. Org. Lett. 2014, 16, 3942-3945. DOI: 10.1021/ol501742a
M31. Xiaomin Sun, Feng Yu, Tingting Ye, Xinmiao Liang, Jinxing Ye*. Catalytic Asymmetric Michael Reactions of α,β-Unsaturated Ketones with Sulfonyl-Containing Nucleophiles: Chiral Synthesis of ®-Muscone and (S)-Celery Ketone. Chem. Eur. J. 2011, 17, 430-434. DOI: 10.1002/chem.201002418
M32. Wenjun Li, Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang, Jinxing Ye*. Catalytic asymmetric michael addition with curcumin derivative. Org. Biomol. Chem. 2011, 9, 2505-2511. DOI: 10.1039/c0ob00757a
M33. Yufeng Zhou, Xin Li, Wenjun Li, Chunlin Wu, Xinmiao Liang*, Jinxing Ye*. Asymmetric organocatalytic michael addition of α, β-unsaturated ketone with 1,2,4-triazole. Synlett 2010, 15, 2357-2360. DOI: 10.1055/s-0030-1258040
M34. Yongping Zhang, Zhimou Guo, Jinxing Ye, Qing Xu, Xinmiao Liang*, Aiwen Lei*. Preparation of novel β-cyclodextrin chiral stationary phase based on click chemistry. J. Chromatography A 2008, 1191, 188-192. DOI: 10.1016/j.chroma.2007.11.018
M35. Feifang Zhang, Jinxing Ye, Qing Zhang, Jiping Chen, Xinmiao Liang*. Enantioseparation of ranolazine using Shiseido chiral CD-PH column by RP-HPLC. Chin. J. Anal. Lab. 2005, 24(7), 48-50. 检索
M36. Jinxing Ye, Feifang Zhang, Qing Zhang, Jiping Chen, Xinmiao Liang*. Chiral separation of β-blocking agents by RP-HPLC. J. Instru. Anal. 2004, 23, 80-82. 检索
（该方向为近年布局的新兴方向，成果处于在研 / 同行评议阶段）
C1. Maolin Sun, Rixin Shao, Haoxiang Chen, Tianmin Guo, Hualiang Chen, Wuqiang Song, Chaoming Liang, Ruihua Cheng*, Tao Li*, Jinxing Ye*. Continuous flow modular synthetic platform for accelerated drug discovery. Eur. J. Med. Chem. 2026, 315, 118934. DOI: 10.1016/j.ejmech.2026.118934
C2. Xin Wang, Yueyue Ma, Jinxing Ye*, Zhen Liu and Ruihua Cheng*. Theoretical investigation of mechanism on nickel-catalyzed electrochemical cross-coupling of aryl bromides and arylamines. Catal. Sci. Technol. 2023, 13(4), 1032-1040. DOI: 10.1039/d2cy01798a
C3. Yan Xiong, Chengyu Liu, Lei Zhang, Xin Wang, Jiaxin Yang, Zhen Liu*, Jinxing Ye*, Ruihua Cheng*. Theoretical exploration of mechanism and ligand effects of asymmetric hydrogenation of β-amino ketone catalyzed by an iridium-PNN catalyst. Organometallics 2023, 42(9), 757-768. DOI: 10.1021/acs.organomet.2c00327
C4. Jingyi Wang, Chengyu Liu, Liming Cao, Yan Xiong, Jinxing Ye*, Zhen Liu*, Ruihua Cheng*. Theoretical investigation of mechanism and ligand effects on half-sandwich iridium complexes for direct reductive amination. Mol. Catal. 2022, 517, 112050. DOI: 10.1016/j.mcat.2021.112050
C5. Jiehan Hu*, Jinxing Ye, Guobao Cheng, Xiangyun Long. Quantum chemistry ab initio calculation of vibration spectrum of β-elemene. Spectrosc. Spect. Anal. 2001, 21, 163-168. 检索
C6. Jinxing Ye, Guobao Cheng, Jiehan Hu*. Study on computational chemistry of elemene and its derivatives: ι. theoretical calculation of 13C NMR chemical shifts of β-elemene. Chin. J. Mag. Reson. 2000, 17, 115-120. 检索
（该方向为近年布局的新兴方向）
A1. Lei Zhang, Liming Cao, Maolin Sun, Chaoming Liang, Lei Yang, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*. One-pot synthesis of chiral 1-aryl-2-aminoethanols via Ir-catalyzed asymmetric hydrogenation. Chem. Eur. J. 2023, 29(29), e202300367. DOI: 10.1002/chem.202300367
A2. Lei Zhang, Chengyu Liu, Maolin Sun, Chaoming Liang, Liming Cao, Xiantong Yao, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*. Iridium-catalyzed asymmetric hydrogenation of simple ketones with tridentate PNN ligands bearing unsymmetrical vicinal diamines. J. Org. Chem. 2023, 88(5), 2942-2951. DOI: 10.1021/acs.joc.2c02676
A3. Huan Dong, Zhiheng Feng, Maolin Sun, Shihao Zhu, Jinghong Zhou, Wei Li, Jinxing Ye, Ruihua Cheng,. A wide range of poly(glycolic acid)-based di- and tri-block polyesters by a single organocatalyst: Synthesis and characterization. J. Polym. Sci. 2023. DOI: 10.1002/pol.20230231
A4. Yan Xiong, Chengyu Liu, Lei Zhang, Xin Wang, Jiaxin Yang, Zhen Liu, Jinxing Ye*, Ruihua Cheng*. Theoretical exploration of mechanism and ligand effects of asymmetric hydrogenation of β-amino ketone catalyzed by an iridium-PNN catalyst. Organometallics 2023, 42(9), 757-768. DOI: 10.1021/acs.organomet.2c00327
A5. Yutao Tong, Ruihua Cheng*, Huan Dong, Zhen Liu, Jinxing Ye, Boping Liu*. Highly active bifunctional dual-arm organoboron catalysts bearing cooperative intramolecular structures for the copolymerization of CO2 and epoxides. J. CO2 Util. 2022, 60, 101979. DOI: 10.1016/j.jcou.2022.101979
A6. Jingyi Wang, Chengyu Liu, Liming Cao, Yan Xiong, Jinxing Ye*, Zhen Liu*, Ruihua Cheng*. Theoretical investigation of mechanism and ligand effects on half-sandwich iridium complexes for direct reductive amination. Mol. Catal. 2022, 517, 112050. DOI: 10.1016/j.mcat.2021.112050
A7. Lei Zhang, Chengyu Liu, Lei Yang, Liming Cao, Caoming Liang, Maolin Sun, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*. Synthesis of triarylphosphines from arylammonium salts via one-pot transition-metal-free C-P coupling. Org. & Biomol. Chem. 2022, 20(19), 3897-3901. DOI: 10.1039/d2ob00547f
A8. Chao Shan, Jinping Xu, Liming Cao, Caoming Liang, Ruihua Cheng, Xiantong Yao, Maolin Sun*, Jinxing Ye*. Rapid synthesis of α-chiral piperidines via a highly diastereoselective continuous flow protocol. Org. Lett. 2022, 24, 3205-3210. DOI: 10.1021/acs.orglett.2c00975
A9. Chao Shan, Liming Cao, Lei Yang, Ruihua Cheng, Xiantong Yao, Caoming Liang, Maolin Sun*, Jinxing Ye*. Construction of an alpha-chiral pyrrolidine library with a rapid and scalable continuous flow protocol. React. Chem. Eng. 2022, 7, 1779-1785. DOI: 10.1039/d2re00145d
A10. Chuncheng Zou, Lei Yang, Lei Zhang, Chengyu Liu, Yueyue Ma, Gonghua Song, Zhen Liu*, Ruihua Cheng*, and Jinxing Ye*. Enantioselective vinylogous conia-ene reaction catalyzed by a disilver(i)/bisdiamine complex. ACS Catal. 2021, 11, 6865-6871. DOI: 10.1021/acscatal.1c01033
A11. Chuncheng Zou, Yanting Lv, Min Lu, Xin Li, Lei Zhang, Lei Yang, Zhen Liu, Yanxiong Ke, Gonghua Song, Jinxing Ye*. Regioselective and diastereodivergent organocatalytic asymmetric vinylogous Michael addition. Org. Chem. Front. 2021, 8, 4758-4766. DOI: 10.1039/d1qo00371b
A12. Chuncheng Zou, Yuanyuan Han, Chuikun Zeng, Tony Y. Zhang, Jinxing Ye*, Gonghua Song*. Remote regioselective organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethyl isatin ketimines with cyclic 2,4-dienones. Chin. Chem. Lett. 2020, 31, 377-380. DOI: 10.1016/j.cclet.2019.07.052
A13. Min Lu, Hong Li, Chuncheng Zou, Jianchang Li, Chengyu Liu, Maolin Sun, Yueyue Ma, Ruihua Cheng, Jinxing Ye*. Primary amine catalyzed diastereo- and enantioselective michael reaction of thiazolones and α,β-unsaturated ketones. Org. Biomol. Chem. 2019, 17(42), 9305-9312. DOI: 10.1039/c9ob02067e
A14. Guibing Wu, Jingwen Wang, Chengyu Liu, Maolin Sun, Lei Zhang, Yueyue Ma, Ruihua Cheng, Jinxing Ye*. Transition metal-free, visible-light-mediated construction of α,β-diamino esters via decarboxylative radical addition at room temperature. Org. Chem. Front. 2019, 6(13), 2245-2249. DOI: 10.1039/c9qo00407f
A15. Huicai Huang*, Xue Lu, Yukang Mao, Jinxing Ye*. Asymmetric synthesis of highly functionalized furanones via direct michael reactions mediated by a bulky primary amine. Org. Chem. Front. 2019, 6(8), 1080-1083. DOI: 10.1039/c8qo01132j
A16. Xiaoqian Yuan, Shupeng Dong, Zhen Liu, Guibing Wu, Chuncheng Zou, Jinxing Ye*. Enantioselective Michael addition of photogenerated o-quinodimethanes to enones catalyzed by chiral amino acid esters. Org. Lett. 2017, 19, 2322-2325. DOI: 10.1021/acs.orglett.7b00862
A17. Kaihe Zou, Xin-Yan Wu, Jinxing Ye*. Brønsted Acid-Catalyzed Aza-Mannich reaction of N-Boc aminals: access to multifunctional rhodanine/hydantoin derivatives. Res. Chem. Intermediat. 2017, 43, 4503-4516. DOI: 10.1007/s11164-017-2892-9
A18. Chuncheng Zou, Chuikun Zeng, Zhen Liu, Min Lu, Xiaohua Sun, Jinxing Ye*. gamma’-Selective functionalization of cyclic enones: construction of a chiral quaternary carbon center by [4+2] cycloaddition/retro-Mannich reaction with 3-substituted maleimides. Angew. Chem. Int. Ed. 2016, 55(46), 14257-14261. DOI: 10.1002/anie.201605790
A19. Song Zhang, Junzhu Lu, Jinxing Ye*, Wei-liang Duan*. Asymmetric C-H arylation for the synthesis of planar chiral ferrocenes: controlling enantioselectivity using chiral phosphoric acids. Chin. J. Org. Chem. 2016, 36, 752-759. DOI: 10.6023/cjoc201602032
A20. Xiaoqian Yuan, Xinxin Wu, Shupeng Dong, Guibing Wu, Jinxing Ye*. Brønsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: efficient synthesis of 2-arylindols. Org. Biomol. Chem. 2016, 14, 7447-7450. DOI: 10.1039/c6ob01239f
A21. Xiaohua Sun, Jie Fei, Chuncheng Zou, Min Lu, Jinxing Ye*. Remote stereocontrolled asymmetric 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolinethiones. RSC Advances 2016, 6, 106676-106679. DOI: 10.1039/c6ra19916j
A22. Haoxiang Hu, Chunna Meng, Yun Dong, Xin Li, and Jinxing Ye*. Catalytic asymmetric formal aza-diels–alder reactions of α,β-unsaturated ketones and 3H-indoles. ACS Catal. 2015, 5, 3700-3703. DOI: 10.1021/acscatal.5b00680
A23. Xiaodong Gu, Tingting Guo, Yuanyuan Dai, Allegra Franchino, Jie Fei, Chuncheng Zou, Darren J. Dixon*, Jinxing Ye*. Direct catalytic asymmetric doubly vinylogous michael addition of α,β-unsaturated γ-butyrolactams to dienones. Angew. Chem. Int. Ed. 2015, 54, 10249-10253. DOI: 10.1002/anie.201504276
A24. Yuan Wei, Zunwu Liu, Xinxin Wu, Jie Fei, Xiaoqian Yuan, Jinxing Ye*. Remote construction of chiral vicinal tertiary and quaternary centers by catalytic asymmetric 1,6-conjugate addition of prochiral carbon nucleophiles to cyclic dienones. Chem. Eur. J. 2015, 21, 18921-18924. DOI: 10.1002/chem.201503530
A25. Jie Fei, Qingqing Qian, Xiaohua Sun, Xiaodong Gu, Chuncheng Zou, and Jinxing Ye*. Organocatalytic enantioselective formal [4+2] cycloaddition of enones with cyclic N-sulfonylimines and methylene chromene for chiral spirocyclic compounds. Org. Lett. 2015, 5296-5299. DOI: 10.1021/acs.orglett.5b02667
A26. Yuan Wei, Shigang Wen, Zunwu Liu, Xinxin Wu, Bubing Zeng, and Jinxing Ye*. Diastereodivergent catalytic asymmetric michael addition of 2-oxindoles to α,β-unsaturated ketones by chiral diamine catalysts. Org. Lett. 2015, 17, 2732-2735. DOI: 10.1021/acs.orglett.5b01149
A27. Xiaodong Gu, Yuanyuan Dai, Tingting Guo, Allegra Franchino, Darren J. Dixon, and Jinxing Ye*, A general, scalable. A General, Scalable, Organocatalytic Nitro-Michael Addition to Enones: Enantioselective Access to All-Carbon Quaternary Stereocenters. Org. Lett. 2015, 17, 1505-1508. DOI: 10.1021/acs.orglett.5b00387
A28. Kaihe Zou, Jinxing Ye*, Xin-Yan Wu*. Acid-catalyzed Efficient Friedel–Crafts reaction of indoles with N-Boc aminals. Tetrahedron 2015, 71, 7869-7873. DOI: 10.1016/j.tet.2015.08.030
A29. Kaihe Zou, Jinxing Ye*, Xin-Yan Wu*. An efficient synthesis of styrenyl enamides from 4-aryl-2-oxazolidinones in the presence of strong base. Tetrahedron Lett. 2015, 56, 5517-5520. DOI: 10.1016/j.tetlet.2015.08.026
A30. Junzhu Lu, Jinxing Ye, Wei-Liang Duan*. Palladium-catalyzed asymmetric 1,6-addition of diarylphosphines to alpha, beta, gamma, delta-unsaturated sulfonic esters: controlling regioselectivity by rational selection of electron-withdrawing groups. Chem. Commun. 2014, 50, 698-700. DOI: 10.1039/c3cc46290k
A31. Xin Li, Min Lu, Yun Dong, Wenbin Wu, Qingqing Qian, Jinxing Ye*, & Darren J Dixon*. Diastereodivergent organocatalytic asymmetric vinylogous Michael reactions. Nature Commun. 2014, 5. DOI: 10.1038/ncomms5479
A32. Wenbin Wu, Xin Li, Huicai Huang, Xiaoqian Yuan, Junzhu Lu, Kailong Zhu, Jinxing Ye*. Asymmetric intramolecular oxa-Michael reactions of cyclohexadienones catalyzed by a primary amine salt. Angew. Chem. Int. Ed. 2013, 52, 1743-1747. DOI: 10.1002/anie.201206977
A33. Kailong Zhu, Huicai Huang, Wenbin Wu, Yuan Wei, Jinxing Ye*. Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives. Chem. Commun. 2013, 49, 2157-2159. DOI: 10.1039/c3cc00023k
A34. Huicai Huang, Wenbin Wu, Kailong Zhu, Juan Hu, Jinxing Ye*. Highly diastereo- and enantioselective cross-cascade reactions of different enones. Chem. Eur. J. 2013, 19, 3838-3841. DOI: 10.1002/chem.201204520
A35. Junzhu Lu, Jinxing Ye, Wei-Liang Duan*. Palladium-catalyzed asymmetric addition of diarylphosphines to alpha,beta-unsaturated sulfonic esters for the synthesis of chiral phosphine sulfonate compounds. Org. Lett. 2013, 15, 5016-5019. DOI: 10.1021/ol402351c
A36. Wenbin Wu, Xiaoqian Yuan, Juan Hu, Xinxin Wu, Yuan Wei, Zunwu Liu, Junzhu Lu, Jinxing Ye*. Catalytic asymmetric construction of chiral hydropyridazines via conjugate addition of N-monosubstituted hydrazones to enones. Org. Lett. 2013, 15, 4524-4527. DOI: 10.1021/ol4020865
A37. Wenbin Wu, Huicai Huang, Xiaoqian Yuan, Kailong Zhu, Jinxing Ye*. Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine. Chem. Commun. 2012, 48, 9180-9182. DOI: 10.1039/c2cc34321e
A38. Huicai Huang, Kailong Zhu, Wenbin Wu, Zhichao Jin, Jinxing Ye*. Highly diastereoselective and enantioselective michael addition of 5h-oxazol-4-ones to α, β-unsaturated ketones catalyzed by a new bifunctional organocatalyst with broad substrate scope and applicability. Chem. Commun. 2012, 48, 461-463. DOI: 10.1039/c1cc15928c
A39. Feng Yu, Haoxiang Hu, Xiaodong Gu, Jinxing Ye*. Asymmetric Michael addition of substituted rhodanines to α,β-unsaturated ketones catalyzed by bulky primary amines. Org. Lett. 2012, 14, 2038-2041. DOI: 10.1021/ol300489q
A40. Zhichao Jin, Huicai Huang, Wenjun Li, Xiaoyan Luo, Xinmiao Liang, Jinxing Ye*. Enantioselective organocatalytic synthesis of oxazolidine derivatives through a one-pot cascade reaction. Adv. Synth. Catal. 2011, 353, 343-348. DOI: 10.1002/adsc.201000647
A41. Huicai Huang, Zhichao Jin, Kailong Zhu, Xinmiao Liang, Jinxing Ye*. Highly diastereo- and enantioselective synthesis of 5-substituted 3-pyrrolidin-2-ones through a direct vinylogous michael addition under multifunctional catalysis. Angew. Chem. Int. Ed. 2011, 50, 3232-3235. DOI: 10.1002/anie.201008255
A42. Wenjun Li, Xin Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Highly diastereo- and enantioselective one-pot michael-aldol reactions of α, β-unsaturated aldehydes with imidazole derivatives. Chem. Commun. 2011, 47, 8325-8327. DOI: 10.1039/c1cc12300a
A43. Xiaomin Sun, Feng Yu, Tingting Ye, Xinmiao Liang, Jinxing Ye*. Catalytic Asymmetric Michael Reactions of α,β-Unsaturated Ketones with Sulfonyl-Containing Nucleophiles: Chiral Synthesis of ®-Muscone and (S)-Celery Ketone. Chem. Eur. J. 2011, 17, 430-434. DOI: 10.1002/chem.201002418
A44. Xiaoyan Luo, Zhiqiang Zhou, Feng Yu, Xin Li, Xinmiao Liang, and Jinxing Ye*. Asymmetric vinylogous Michael reaction of α, β-unsaturated aldehyde with buteno-4-lactone. Chem. Lett. 2011, 40, 518-520. DOI: 10.1246/cl.2011.518
A45. Wenjun Li, Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang, Jinxing Ye*. Catalytic asymmetric michael addition with curcumin derivative. Org. Biomol. Chem. 2011, 9, 2505-2511. DOI: 10.1039/c0ob00757a
A46. Zhichao Jin, Feng Yu, Xiao Wang, Huicai Huang, Xiaoyan Luo, Xinmiao Liang, Jinxing Ye*. A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives. Org. Biomol. Chem. 2011, 9, 1809-1816. DOI: 10.1039/c0ob00669f
A47. Xiaoyan Luo, Zhichao Jin, Pengfei Li, Jiabin Gao, Weimin Yue, Xinmiao Liang, Jinxing Ye*. Catalytic asymmetric michael addition of α, β-unsaturated aldehydes with ni(ii) complexes of the schiff base of glycine. Org. Biomol. Chem. 2011, 9, 793-801. DOI: 10.1039/c0ob00221f
A48. Zhichao Jin, Xiao Wang, Huicai Huang, Xinmiao Liang, Jinxing Ye*. Diastereo- and enantioselective synthesis of oxazine and oxazolidine derivatives with chiral quaternary carbon center under multifunctional catalysis. Org. Lett. 2011, 13, 564-567. DOI: 10.1021/ol102643a
A49. Xiaoyan Luo, Zhiqiang Zhou, Xin Li, Xinmiao Liang, Jinxing Ye*. Enantioselective organocatalytic phospha-michael reaction of α,β-unsaturated aldehydes. RSC Advances 2011, 1, 698-705. DOI: 10.1039/c1ra00269d
A50. Juanjuan Yang, Huicai Huang, Zhichao Jin, Wenbin Wu, Jinxing Ye*. Diastereoselective synthesis of bicyclo[2.2.2]octan-2-one derivatives through an unexpected organocatalytic tandem Michael-Michael reaction. Synthesis 2011, 1984-1987. DOI: 10.1055/s-0030-1260052
A51. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye*. Asymmetric direct michael addition of acetophenone to α, β-unsaturated aldehyde. Synthesis 2011, 1085-1091. DOI: 10.1055/s-0030-1258459
A52. Wenjun Li, Xin Li, Tingting Ye, Wenbin Wu, Xinmiao Liang, Jinxing Ye*. Asymmetric organocatalytic Michael/α-alkylation reaction of α, β-unsaturated aldehyde with chloroacetophenone. Tetrahedron Lett. 2011, 52, 2715-2718. DOI: 10.1016/j.tetlet.2011.03.079
A53. Huicai Huang, Feng Yu, Zhichao Jin, Wenjun Li, Wenbin Wu, Xinmiao Liang*, Jinxing Ye*. Asymmetric vinylogous Michael reaction of α, β-unsaturated ketones with γ-butenolide under multifunctional catalysis. Chem. Commun. 2010, 46, 5957-5959. DOI: 10.1039/c0cc01054e
A54. Feng Yu, Xiaomin Sun, Zhichao Jin, Shigang Wen, Xinmiao Liang*, Jinxing Ye*. Enantioselective michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN Salt. Chem. Commun. 2010, 46, 4589-4591. DOI: 10.1039/c0cc00774a
A55. Shigang Wen, Pengfei Li, Haibo Wu, Feng Yu, Xinmiao Liang*, Jinxing Ye*. Enantioselective organocatalytic phospha-Michael reaction of α, β-unsaturated ketones. Chem. Commun. 2010, 46, 4806-4808. DOI: 10.1039/c0cc00094a
A56. Feng Yu, Zhichao Jin, Huicai Huang, Tingting Ye, Xinmiao Liang, Jinxing Ye*. A highly efficient asymmetric Michael addition of α, α-disubstituted aldehydes to maleimides catalyzed by primary amine thiourea salt. Org. Biomol. Chem. 2010, 8, 4767-4774. DOI: 10.1039/c0ob00154f
A57. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang*, Jinxing Ye*. Asymmetric organocatalytic Michael addition of anthrone to enone. Org. Biomol. Chem. 2010, 8, 3244-3250. DOI: 10.1039/b927421a
A58. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye*. Enantioselective michael reaction of α-alkyl-β-keto esters and enones under multifunctional catalysis. Org. Lett. 2010, 12, 5218-5221. DOI: 10.1021/ol102256v
A59. Yufeng Zhou, Xin Li, Wenjun Li, Chunlin Wu, Xinmiao Liang*, Jinxing Ye*. Asymmetric organocatalytic michael addition of α, β-unsaturated ketone with 1,2,4-triazole. Synlett 2010, 15, 2357-2360. DOI: 10.1055/s-0030-1258040
A60. Pengfei Li, Shigang Wen, Feng Yu, Qiaoxia Liu, Wenjun Li, Yongcan Wang, Xinmiao Liang*, Jinxing Ye*. Enantioselective organocatalytic Michael addition of malonates to α, β-unsaturated ketones. Org. Lett. 2009, 11, 753-756. DOI: 10.1021/ol802892h
A61. Yongcan Wang, Pengfei Li, Xinmiao Liang*, Jinxing Ye*. Base - Base bifunctional catalysis: a practical strategy for asymmetric Michael addition of malonates to α, β-unsaturated aldehydes. Adv. Synth. Catal. 2008, 350, 1383-1389. DOI: 10.1002/adsc.200800070
A62. Pengfei Li, Yongcan Wang, Xinmiao Liang*, Jinxing Ye*. Asymmetric multifunctional organocatalytic Michael addition of nitroalkanes to α, β-unsaturated ketones. Chem. Commun. 2008, 3302-3304. DOI: 10.1039/b804540b
A63. Yongcan Wang, Pengfei Li, Xinmiao Liang*, Tony Y. Zhang, Jinxing Ye*. An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to α, β-unsaturated aldehydes. Chem. Commun. 2008, 1232-1234. DOI: 10.1039/b717000a
A64. Yongcan Wang, Jinxing Ye*, Xinmiao Liang*. Convenient preparation of chiral α, β-epoxyketones via claisen-schmidt condensation-epoxidation sequence. Adv. Synth. Catal. 2007, 349, 1033-1036. DOI: 10.1002/adsc.200600592
A65. A. L. Tillman, Jinxing Ye, D. J. Dixon*. Direct enantio- and diastereoselective Mannich reactions of malonate and beta-keto esters with N-Boc- and N-Cbz-aldimines catalysed by a bifunctional cinchonine derivative. Chem. Commun. 2006, 1191-1193. DOI: 10.1039/b515725k
A66. Jinxing Ye, Darren J. Dixon*, Peter S. Hynes. Highly enantioselective Michael addition of malonate esters to nitro olefins using a cinchonine-derived bifunctional organic catalyst. Chem. Commun. 2005, 4481-4483. DOI: 10.1039/b508833j
A67. Yongcan Wang, Jinxing Ye, Xinmiao Liang*. Research on the epoxidation of enone under micellar condition. Chin. J. Org. Chem. 2005, 25(8), 969-971. 检索
A68. Jinxing Ye, Yongcan Wang, Jiping Chen, Xinmiao Liang*. Trichloroisocyanuric acid: a convenient oxidation reagent for phase-transfer catalytic epoxidation of enones under non-aqueous conditions. Adv. Synth. Catal. 2004, 346, 691-696. DOI: 10.1002/adsc.200303227
A69. Jinxing Ye, Yongcan Wang, Renhua Liu, Guofu Zhang, Qing Zhang, Jiping Chen, Xinmiao Liang*. A highly enantioselective phase-transfer catalyzed epoxidation of enones with a mild oxidant of trichloroisocyanuric acid. Chem. Commun. 2003, 2714-2715. DOI: 10.1039/b308042k
E1. Youtian Fu, Ling Zhang, Jiahao Li, Zixuan Fan, Yueyue Ma*, Jinxing Ye*. Direct electrochemical oxidation of alkylarenes to aryl aldehydes and ketones. Chem. Commun. 2026, 62, 14776-14780. DOI: 10.1039/d6cc02433e
E2. Xiantong Yao, Qinghua Zhong, Xin Yang, Wenhui Huang, Ziqi Fang, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*. Visible-light-induced copper-catalyzed coupling reaction of aryl halides with phenols at room temperature. Org. Lett. 2026, 28, 5686-5692. DOI: 10.1021/acs.orglett.6c00657
E3. Xiantong Yao, Ruiyuan Peng, Xin Yang, Jinheng Zheng, Weijun Zhong, Qinghua Zhong, Zhengjie Wang, Dali Yang, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*. Visible-light-promoted copper-catalyzed etherification of aryl bromides via energy transfer. Org. Lett. 2025, 27, 7313-7318. DOI: 10.1021/acs.orglett.5c01919
E4. Xin Wang, Yueyue Ma, Jinxing Ye*, Zhen Liu and Ruihua Cheng*. Theoretical investigation of mechanism on nickel-catalyzed electrochemical cross-coupling of aryl bromides and arylamines. Catal. Sci. Technol. 2023, 13(4), 1032-1040. DOI: 10.1039/d2cy01798a
E5. Ling Zhang, Youtian Fu, Lei Yang, Liming Cao, Junjun Yi, Maolin Sun, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*. Direct electrochemical synthesis of quinones from simple aromatics and heteroaromatics. Chem. Commun. 2023, 59(47), 7255-7258. DOI: 10.1039/d3cc01661g
E6. Pufan Ni, Lei Yang, Jiasheng Yang, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*, Weiping Zhu. para-Selective, direct C(sp2)-H alkylation of electron-deficient arenes by the electroreduction process. J. Org. Chem. 2023, 88(9), 5248-5253. DOI: 10.1021/acs.joc.2c02412
E7. Lei Yang, Maolin Sun, Liming Cao, Chaoming Liang, Jiasheng Yang, Junjun Yi, Ruihua Cheng, Yueyue Ma*, and Jinxing Ye*. Electricity-driven three-component reductive coupling reaction for the synthesis of diarylmethylamine. Chem. Commun. 2022, 58, 13345-13348. DOI: 10.1039/d2cc05330f
E8. Pufan Ni, Lei Yang, Yi Shen, Lei Zhang, Yueyue Ma, Maolin Sun, Ruihua Cheng*, and Jinxing Ye*. Synthesis of phenols from aryl ammonium salts under mild conditions. J. Org. Chem. 2022, 87, 12677-12687. DOI: 10.1021/acs.joc.2c01133
E9. Ling Zhang, Youtian Fu, Yi Shen, Chengyu Liu, Maolin Sun, Ruihua Cheng, Weiping Zhu, Xuhong Qian, Yueyue Ma*, Jinxing Ye*. Ritter-type amination of C(sp(3))-H bonds enabled by electrochemistry with SO42-. Nat. Commun. 2022, 13. DOI: 10.1038/s41467-022-31813-3
E10. Yueyue Ma, Jufei Hong, Xiantong Yao, Chengyu Liu, Ling Zhang, Youtian Fu, Maolin Sun, Ruihua Cheng, Zhong Li*, Jinxing Ye*. Aminomethylation of aryl bromides by nickel-catalyzed electrochemical redox neutral cross coupling. Org. Lett. 2021, 23, 9387-9392. DOI: 10.1021/acs.orglett.1c03500
E11. Yueyue Ma, Xiantong Yao, Lei Zhang, Pufan Ni, Ruihua Cheng, Jinxing Ye*. Direct arylation of α-amino C(sp3)-H bonds by convergent paired electrolysis. Angew. Chem. Int. Ed. 2019, 58(46), 16548-16552. DOI: 10.1002/anie.201909642
E12. Yueyue Ma, Jufeng Lv, Chengyu Liu, Xiantong Yao, Guoming Yan, Wei Yu, Jinxing Ye*. Electrochemical [4+2] annulation-rearrangement-aromatization of styrenes: synthesis of naphthalene derivatives. Angew. Chem. Int. Ed. 2019, 58(20), 6756-6760. DOI: 10.1002/anie.201902315
E13. Guibing Wu, Jingwen Wang, Chengyu Liu, Maolin Sun, Lei Zhang, Yueyue Ma, Ruihua Cheng, Jinxing Ye*. Transition metal-free, visible-light-mediated construction of α,β-diamino esters via decarboxylative radical addition at room temperature. Org. Chem. Front. 2019, 6(13), 2245-2249. DOI: 10.1039/c9qo00407f
E14. Shupeng Dong, Guibing Wu, Xiaoqian Yuan, Chuncheng Zou, Jinxing Ye*. Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source. Org. Chem. Front. 2017, 4, 2230-2234. DOI: 10.1039/c7qo00453b
E15. Xiaoqian Yuan, Shupeng Dong, Zhen Liu, Guibing Wu, Chuncheng Zou, Jinxing Ye*. Enantioselective Michael addition of photogenerated o-quinodimethanes to enones catalyzed by chiral amino acid esters. Org. Lett. 2017, 19, 2322-2325. DOI: 10.1021/acs.orglett.7b00862
E16. Xiaoqian Yuan, Xinxin Wu, Shupeng Dong, Guibing Wu, Jinxing Ye*. Brønsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: efficient synthesis of 2-arylindols. Org. Biomol. Chem. 2016, 14, 7447-7450. DOI: 10.1039/c6ob01239f
E17. Xinxin Wu, Chunna Meng, Xiaoqian Yuan, Xiaotong Jia, Xuhong Qian and Jinxing Ye*. Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes. Chem. Commun. 2015, 51, 11864-11867. DOI: 10.1039/c5cc04527d
成果见于 Nat. Commun.（2）、Angew. Chem. Int. Ed.（7）、J. Am. Chem. Soc.（1）、ACS Catal.（2）、Org. Lett.（16）、Chem. Commun.（18）、Org. Process Res. Dev.（3）、Chin. Chem. Lett.（5）、J. Flow Chem.（4）、Chem. Eur. J.（4）、Adv. Synth. Catal.（5）、Org. Chem. Front.（4）等期刊，单篇最高被引 516 次。申请专利 50 余项，已获授权 24 项。
国家自然科学基金面上项目：高温高压强腐蚀性反应研究装置设计、反应机理及反应动力学研究（2023—2026）
国家自然科学基金面上项目：基于钛催化循环的汇聚成对电化学合成方法的设计与发展（2021—2024）
国家自然科学基金面上项目：非对映发散的催化不对称共轭加成反应及机理研究（2016—2019）
国家自然科学基金面上项目：具有大位阻基团新型手性伯胺催化剂的设计、应用及催化机理研究（2013—2016）
国家自然科学基金青年基金：一类手性有机催化剂的设计、合成与应用（2010—2012）
广东省“珠江人才计划”领军人才：药物连续制造（2022）
江苏省“双创人才计划”：绿色制药技术（2018）
教育部新世纪优秀人才支持计划：有机催化与不对称合成（2013）
上海市“浦江人才计划”：多功能有机催化不对称 Michael 加成及串联反应（2008）
上海市重大专项子课题：心血管药物连续制造关键原型机研制（2019—2022）
上海市重大专项子课题：连续微纳反应—萃取分离原型机研制（2019—2022）
上海市教委科研创新重点项目：2(5H)呋喃酮、吡咯酮和噻吩酮的不对称 Michael 加成及串联反应方法学发展及应用
广东工业大学百人计划：药物连续合成与制造（2021—2026）
广州伽能生物 / 伽能生物科技（上海）：日化领域原料开发和测试（2022—2029）
山东同成医药：氯代烷烃连续化生产技术开发（2021—2024）
山东潍坊润丰化工：农药中间体连续化工艺开发（2020—2021）
上海中西三维药业：盐酸倍他司汀、甲磺酸雷沙吉兰、盐酸度洛西汀绿色关键工艺开发及应用（2018—2021）
美国礼来（Eli Lilly）：药物合成与分析国际合作（两期）（2007—2010）
广东银美科技：聚甘油系列产品开发（2024—2027）
联合利华全球研发中心（上海）：聚合物染料和相关单体的合成（2010—2011）
中国科学院大连化学物理研究所：药物中间体合成及杂质制备（2007—2008）
“华东理工大学—上药中西三维连续流动合成联合研究中心”（主任，2018—2021）
2012 Thieme Chemistry Journal Award（国际学术奖励）
2020 江苏省科学技术奖三等奖：索非布韦绿色创新技术的研发及产业化（排名第 2）
2019 江苏医药科技奖二等奖：酶催化制备高品质瑞舒伐他汀系列产品（排名第 7）
2018 江苏医药科技奖三等奖：高品质索非布韦中间体绿色合成生产技术（排名第 9）
2022 广东省“珠江人才计划”领军人才
2018 江苏省“双创人才计划”
2013 教育部“新世纪优秀人才支持计划”
2008 上海市“浦江人才计划”
2004 英国皇家学会 The Royal Society Postdoctoral Fellowship
2011 / 2018 两次“天鼎-东岳”研究生奖教金一等奖
2019 华东理工大学“良师益友”我心中的好导师提名奖
2009—2011 华东理工大学校优秀教育工作者
2021.05—至今 广东工业大学生物医药学院，百人特聘教授、博士生导师（2022.01 起任副院长）
2013.11—2015.01 美国加州大学伯克利分校化学系，访问学者（Jeffrey R. Long、Jeffrey Reimer 教授）
2012.09—2021.04 华东理工大学药学院，教授
2007.01—2012.08 华东理工大学药学院，副研究员（2011.09 破格聘任博士生导师）
2005.11—2006.10 日本名古屋大学，博士后（野依良治教授〔诺贝尔化学奖得主〕、齐藤进教授）
2004.11—2005.10 英国曼彻斯特大学，博士后（Darren J. Dixon 教授）
2000.09—2004.08 中国科学院大连化学物理研究所，有机化学博士（梁鑫淼研究员）
1997.09—2000.07 广西大学 / 中科院大连化物所，应用化学硕士
1993.09—1997.07 中南大学化学系，工业分析学士
广东工业大学：生物医药学院副院长（2022—至今）；化工材料部学术分委员会委员/学位分委员会委员；学院学术委员会主任、学位评议组组长
华东理工大学：药学院副院长（2010—2013）、院长助理（2009—2010）
制药工程与过程化学教育部工程研究中心：主任（2018—2020）、主任助理（2007—2009）
华东理工大学制药工程与技术硕 / 博点负责人、学术带头人（2016—2021）
期刊与项目评审：国家自然科学基金、多个省市科技计划项目评审专家
招收：博士研究生；学术型 / 专业型硕士研究生
招聘：面向人工智能（人工智能药学、智能药物设计、计算药剂学、生物信息学等）、合成生物学与代谢工程、蛋白质工程与酶设计、有机合成、药物化学等领域，招聘青年教师与博士后，共同建设交叉方向；欢迎将简历与研究设想发送至邮箱
邮箱：jinxingye@gdut.edu.cn，1584090107@qq.com
地址：广东工业大学生物医药学院制药工程系，广州市番禺区广州大学城外环西路 100 号，510006
合作：企业委托攻关、联合研究中心、连续制造工艺与装备开发，欢迎来函洽谈
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