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叶金星 教授

发布日期:2022-02-22    作者:     来源:     点击:

叶金星 YE JINXING 教授

所属学院:生物医院学院

职务:生物医药学院副院长

研究方向:连续流动合成、微通道反应及装备、绿色制药技术、药物化学、光电催化合成、不对称催化、绿色化学合成、清洁化学工艺、分离与纯化等

导师类别:博士生导师

邮箱:jinxingye@gdut.edu.cn

通讯地址:广东工业大学生物医药学院制药工程系,广州市番禺区广州大学城外环西路100号,510006

招生计划:

博士研究生

学术型/专业型硕士研究生

联系方式:jinxingye@gdut.edu.cn


个人简述:

叶金星,广东工业大学生物医药学院百人特聘教授、博士生导师、副院长。2007年至2021年在华东理工大学药学院工作,先后任副研究员,教授,药学院院长助理、副院长,制药工程与过程化学教育部工程研究中心主任助理、主任。其团队研究领域包括合成化学、药物化学以及制药工艺,具体研究方向主要包括连续流动合成、微通道反应及装备、绿色制药技术、药物化学、光电催化合成、不对称催化、绿色化学合成、清洁化学工艺、分离与纯化等。在研及完成多项国家自然科学基金及省部级项目,与多个企业合作项目。目前本团队在已在国际学术刊物上发表八十余篇论文,包括影响因子大于5的48篇,影响因子大于10.0的11篇。论文包括Nat. Commun., Angew. Chem. Int. Ed., J. Am. Chem. Soc., ACS Catal., Org. Process Res. Dev., Org. Lett., Chem. Commun., Chem. Eur. J., Adv. Synth. & Catal., Org. Chem. Front.等。开发了一系列双功能、多功能手性胺催化体系和新反应,开发了一些实用的均相不对称催化氢化实用工艺、微通道连续反应、工艺与装备,可以应用于医药、农药、兽药及化工中间体的制造过程。


学习经历:

2000.09-2004.08 中国科学院大连化学物理研究所有机化学博士(导师:梁鑫淼研究员)

1997.09-2000.07 广西大学化学化工学院应用化学硕士(导师:龙翔云教授、胡皆汉研究员、程国宝研究员)

1993.09-1997.07 中南大学化学系工业分析学士(导师:任凤莲教授)

工作经历:

2012.09-2021.04 华东理工大学药学院教授

2007.01-2012.08 华东理工大学药学院,副研究员

2005.11-2006.10 日本名古屋大学化学系博士后(诺贝尔奖获得者野依良治、斎藤進教授研究室)

2004.11-2005.10 英国曼彻斯特大学化学学院博士后(Darren J. Dixon教授实验室)

2004.08-2004.10 中国科学院大连化学物理研究所研究助理(陈吉平研究员课题组)


主持的科研项目:

1. 国家自然科学基金面上项目:高温高压强腐蚀性反应研究装置设计、反应机理及反应动力学研究

2. 广东工业大学百人计划项目:药物连续合成与制造

3. 国家自然科学面上项目基金:基于钛催化循环的汇聚成对电化学合成方法的设计与发展

4. 上海市重大专项

5. 与上海中西三维药业有限公司企业共建研发中心:华东理工大学-上药中西连续流动合成联合研究中心

6. 几个企业合作项目

7. 国家自然科学基金面上项目:非对映发散的催化不对称共轭加成反应及机理研究

8. 教育部项目:新世纪优秀人才支持计划

9. 国家自然科学基金面上项目:具有大位阻基团新型手性伯胺催化剂的设计、应用及催化机理研究

10. 上海市教委重点科研项目:2(5H)呋喃酮、吡咯酮和噻吩酮的不对称Michacl加成及串联反应方法学发展及应用

11. 国家自然科学基金青年基金:一类手性有机催化剂的设计、合成与应用

12. 美国礼来制药项目:药物合成与分析

13. 上海市科委浦江人才计划:多功能有机催化不对称Michael加成及串联反应研究

14. 中国科学院大连化学物理研究所合作项目:药物中间体合成及杂质制备项目


发表的论文:

97. Huan Dong, Zhiheng Feng, Maolin Sun, Shihao Zhu, Jinghong Zhou, Wei Li, Jinxing Ye, Ruihua Cheng,* A wide range of poly(glycolic acid)-based di- and tri-block polyesters by a single organocatalyst: Synthesis and characterization, J. Polym. Sci., 2023, DOI:10.1002/pol.20230231.

96. Ling Zhang, Youtian Fu, Lei Yang, Liming Cao, Junjun Yi, Maolin Sun, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*, Direct electrochemical synthesis of quinones from simple aromatics and heteroaromatics, Chem. Commun., 2023, 59(47), 7255-7258.

95. Yan Xiong, Chengyu Liu, Lei Zhang, Xin Wang, Jiaxin Yang, Zhen Liu*, Jinxing Ye*, Ruihua Cheng*, Theoretical exploration of mechanism and ligand effects of asymmetric hydrogenation of β-amino ketone catalyzed by an iridium-PNN catalyst, Organometallics, 2023, 42(9), 757-768.

94. Lei Zhang, Liming Cao, Maolin Sun, Chaoming Liang, Lei Yang, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*, One-pot synthesis of chiral 1-aryl-2-aminoethanols via Ir-catalyzed asymmetric hydrogenation, Chem. Eur. J., 2023, 29(29), e202300367.

93. Lei Zhang, Chengyu Liu, Maolin Sun, Chaoming Liang, Liming Cao, Xiantong Yao, Yueyue Ma, Ruihua Cheng*, Jinxing Ye*, Iridium-catalyzed asymmetric hydrogenation of simple ketones with tridentate PNN ligands bearing unsymmetrical vicinal diamines, J. Org. Chem., 2023, 88(5), 2942-2951.

92. Pufan Ni, Lei Yang, Jiasheng Yang, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*, Weiping Zhu, para-Selective, direct C(sp(2))-H alkylation of electron-deficient arenes by the electroreduction process, J. Org. Chem., 2023, 88(9), 5248-5253.

91. Xin Wang, Yueyue Ma, Jinxing Ye*, Zhen Liu and Ruihua Cheng*, Theoretical investigation of mechanism on nickel-catalyzed electrochemical cross-coupling of aryl bromides and arylamines, Catal. Sci. Technol., 2023, 13(4), 1032-1040.

90. Lei Yang, Maolin Sun, Liming Cao, Chaoming Liang, Jiasheng Yang, Junjun Yi, Ruihua Cheng, Yueyue Ma* and Jinxing Ye*, Electricity-driven three-component reductive coupling reaction for the synthesis of diarylmethylamine, Chem. Commun., 2022, 58, 13345-13348.

89. Pufan Ni, Lei Yang, Yi Shen, Lei Zhang, Yueyue Ma, Maolin Sun, Ruihua Cheng*, and Jinxing Ye*, Synthesis of phenols from aryl ammonium salts under mild conditions, J. Org. Chem., 2022, 87, 19, 12677-12687.

88. Lei Zhang, Chengyu Liu, Lei Yang, Liming Cao, Caoming Liang, Maolin Sun, Yueyue Ma,  Ruihua Cheng*, Jinxing Ye*, Synthesis of triarylphosphines from arylammonium salts via one-pot transition-metal-free C-P coupling. Org. & Biomol. Chem., 2022, 20(19), 3897-3901.

87. Ling Zhang, Youtian Fu, Yi Shen, Chengyu Liu, Maolin Sun, Ruihua Cheng, Weiping Zhu, Xuhong Qian, Yueyue Ma*, Jinxing Ye*, Ritter-type amination of C(sp(3))-H bonds enabled by electrochemistry with SO42-. Nat. Commun., 2022, 13, 4138.

86. Hongwei Zhang, Ying Liu, Ling Zhang, Xiong Wang, He Sun, Chengyu Liu, Jinxing Ye,  Ruihua Cheng*, Direct reductive amination from ketones, aldehydes to synthesize amines using N, S-dual doped Co/C catalyst. Catal. Lett., 2022. https://doi.org/10.1007/s10562-021-03911-2

85. Jingyi Wang, Chengyu Liu, Liming Cao, Yan Xiong, Jinxing Ye*, Zhen Liu*, Ruihua Cheng*, Theoretical investigation of mechanism and ligand effects on half-sandwich iridium complexes for direct reductive amination. Mol. Catal., 2022, 517, 112050.

84. Yutao Tong, Ruihua Cheng*, Huan Dong, Zhen Liu, Jinxing Ye, Boping Liu*, Highly active bifunctional dual-arm organoboron catalysts bearing cooperative intramolecular structures for the copolymerization of COand epoxides. J. CO2 Util., 2022, 60, 101979.

83. Chao Shan, Jinping Xu, Liming Cao, Caoming Liang, Ruihua Cheng, Xiantong Yao, Maolin Sun*, Jinxing Ye*, Rapid synthesis of α-chiral piperidines via a highly diastereoselective continuous flow protocol. Org. Lett., 2022, 24 (17), 3205-3210.

82. Chao Shan, Liming Cao, Lei Yang, Ruihua Cheng, Xiantong Yao, Caoming Liang, Maolin Sun*, Jinxing Ye*, Construction of an alpha-chiral pyrrolidine library with a rapid and scalable continuous flow protocol. React. Chem. Eng., 2022, 7 (8), 1779-1785.

81. Yueyue Ma, Jufei Hong, Xiantong Yao, Chengyu Liu, Ling Zhang, Youtian Fu, Maolin Sun,  Ruihua Cheng,  Zhong Li*, Jinxing Ye*, Aminomethylation of aryl bromides by nickel-catalyzed electrochemical redox neutral cross coupling. Org. Lett., 2021, 23 (24), 9387-9392.

80. Chuncheng Zou, Lei Yang, Lei Zhang, Chengyu Liu, Yueyue Ma, Gonghua Song, Zhen Liu*, Ruihua Cheng*, and Jinxing Ye*, Enantioselective vinylogous conia-ene reaction catalyzed by a disilver(i)/bisdiamine complex, ACS Catal., 2021, 11, 6865–6871.

79. Chuncheng Zou, Yanting Lv, Min Lu, Xin Li, Lei Zhang, Lei Yang, Zhen Liu, Yanxiong Ke, Gonghua Song, Jinxing Ye*, Regioselective and diastereodivergent organocatalytic asymmetric vinylogous Michael addition, Org. Chem. Front., 2021, 8 , 4758-4766.

78. Maolin Sun, Jingxin Yang, Youtian Fu, Chaoming Liang, Hong Li, Guoming Yan, Chao Yin, Wei Yu, Yueyue Ma*, Ruihua Cheng*, and Jinxing Ye*, Continuous flow process for the synthesis of betahistine via aza-Michael-type reaction in water, Org. Process Res. Dev., 2021, 25, 1160–1166.

77. Chaoming Liang, Maolin Sun, Xinyuan Shen, Chao Shan, Weijuan Wang, Ruihua Cheng, and Jinxing Ye*, Three-step one-pot process of 3-methyl-5-benzofuranol from amine, aldehydes, and p-benzoquinone, Org. Process Res. Dev., 2021, 25, 4, 810–81676. 

76. Maolin Sun, Chaoming Liang, Xinyuan Shen, Jianchang Li, Ruihua Cheng, Jinxing Ye*, Continuous flow science in an undergraduate teaching laboratory: synthesis of ethylene glycol diacetate using heterogeneous catalysts in continuous flow, J. Chem. Educ., 2021, 98, 572-576.

75. Maolin Sun, Jianchang Li, Chaoming Liang, Chao Shan, Xinyuan Shen, Ruihua Cheng, Yueyue Ma*, Jinxing Ye*, Practical and rapid construction of 2-pyridyl ketone library in continuous flow, J. Flow Chem., 2020, 11 , 91-98.

74. Li Wu, Wei Liu, Jinxing Ye, Ruihua Cheng*, Fast cyclotrimerization of a wide range of isocyanates to isocyanurates over acid/base conjugates under bulk conditions, Cat. Commun., 2020, 145, 106097.(DOI: 10.1016/j.catcom.2020.106097)

73. Chuncheng Zou, Yuanyuan Han, Chuikun Zeng, Tony Y. Zhang, Jinxing Ye*, Gonghua Song*, Remote regioselective organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethyl isatin ketimines with cyclic 2,4-dienones, Chin. Chem. Lett., 2020, 31, 377-380

72. Jun Xu*, Yifei Michelle Liu, Andrew S. Lipton, Jinxing Ye, Gina L. Hoatson, Phillip J. Milner, Thomas M. McDonald, Rebecca L. Siegelman, Alexander C. Forse, Berend Smit, et al, Amine dynamics in diamine-appended Mg2(dobpdc) metal-organic frameworks, J. Phys. Chem. Lett., 2019, 10(22), 7044-7049.

71. Min Lu, Hong Li, Chuncheng Zou, Jianchang Li, Chengyu Liu, Maolin Sun, Yueyue Ma, Ruihua Cheng, Jinxing Ye*, Primary amine catalyzed diastereo- and enantioselective michael reaction of thiazolones and α,β-unsaturated ketones, Org. Biomol. Chem., 2019, 17(42), 9305-9312.

70. Yueyue Ma, Xiantong Yao, Lei Zhang, Pufan Ni, Ruihua Cheng, Jinxing Ye*, Direct arylation of α-amino C(sp3)-H bonds by convergent paired electrolysis, Angew. Chem. Int. Ed., 2019, 58(46), 16548-16552.

69. Chuncheng Zou, Yuanyuan Han, Chuikun Zeng, Tony Y. Zhang, Jinxing Ye*, Gonghua Song*, Remote regioselective organocatalytic asymmetric [3+2] cycloaddition of n-2,2,2-trifluoroethyl isatin ketimines with cyclic 2,4-dienones, Chin. Chem. Lett., 2020, 31(2), 377-380.

68. Guibing Wu, Jingwen Wang, Chengyu Liu, Maolin Sun, Lei Zhang, Yueyue Ma, Ruihua Cheng, Jinxing Ye*, Transition metal-free, visible-light-mediated construction of α,β-diamino esters via decarboxylative radical addition at room temperature, Org. Chem. Front., 2019, 6(13), 2245-2249.

67. Yueyue Ma, Jufeng Lv, Chengyu Liu, Xiantong Yao, Guoming Yan, Wei Yu, Jinxing Ye*, Electrochemical [4+2] annulation-rearrangement-aromatization of styrenes: synthesis of naphthalene derivatives, Angew. Chem. Int. Ed., 2019, 58(20), 6756-6760.

66. Huicai Huang*, Xue Lu, Yukang Mao, Jinxing Ye*, Asymmetric synthesis of highly functionalized furanones via direct michael reactions mediated by a bulky primary amine, Org. Chem. Front., 2019, 6(8), 1080-1083.

65. Shupeng Dong, Guibing Wu, Xiaoqian Yuan, Chuncheng Zou, Jinxing Ye*, Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source, Org. Chem. Front., 2017, 4, 2230-2234.

64. Xiaoqian Yuan, Shupeng Dong, Zhen Liu, Guibing Wu, Chuncheng Zou, Jinxing Ye*, Enantioselective Michael addition of photogenerated o-quinodimethanes to enones catalyzed by chiral amino acid esters, Org. Lett., 2017, 19, 2322-2325.

63. Kaihe Zou, Xin-Yan Wu, Jinxing Ye*, Brønsted Acid-Catalyzed Aza-Mannich reaction of N-Boc aminals: access to multifunctional rhodanine/hydantoin derivatives, Res. Chem. Intermediat., 2017, 43, 4503-4516.

62. Mercedes K. Taylor, Tomče Runčevski, Julia Oktawiec, Miguel I. Gonzalez, Rebecca L. Siegelman, Jarad A. Mason, Jinxing Ye,Jinxing Ye, Craig M. Brown, and Jeffrey R. Long*, Tuning the adsorption-induced phase change in the flexible metal–organic framework Co(bdp), J. Am. Chem. Soc., 2016, 138, 15019-15026.

61. Chuncheng Zou, Chuikun Zeng, Zhen Liu, Min Lu, Xiaohua Sun, Jinxing Ye*, gamma'-Selective functionalization of cyclic enones: construction of a chiral quaternary carbon center by [4+2] cycloaddition/retro-Mannich reaction with 3-substituted maleimides, Angew. Chem. Int. Ed., 2016, 55, 14255-14259.

60. Xiaohua Sun, Jie Fei, Chuncheng Zou, Min Lu, Jinxing Ye*, Remote stereocontrolled asymmetric 1,6-addition/1,4-addition cascade reactions between cyclic dienones and 2-indolinethiones, RSC Advances, 2016, 6, 106676-106679.

59. Song Zhang, Junzhu Lu, Jinxing Ye*, Wei-liang Duan*, Asymmetric C-H arylation for the synthesis of planar chiral ferrocenes: controlling enantioselectivity using chiral phosphoric acids, Chin. J. Org. Chem., 2016, 36, 752-759.

58. Xiaoqian Yuan, Xinxin Wu, Shupeng Dong, Guibing Wu, Jinxing Ye*, Brønsted acid cocatalysis in photocatalytic intramolecular coupling of tertiary amines: efficient synthesis of 2-arylindols, Org. Biomol. Chem., 2016, 14, 7447-7450.

57. Jie Fei, Qingqing Qian, Xiaohua Sun, Xiaodong Gu, Chuncheng Zou, and Jinxing Ye*, Organocatalytic enantioselective formal [4+2] cycloaddition of enones with cyclic N-sulfonylimines and methylene chromene for chiral spirocyclic compounds, Org. Lett., 2015, 5296-5299.

56. Yuan Wei, Zunwu Liu, Xinxin Wu, Jie Fei, Xiaoqian Yuan, Jinxing Ye*, Remote construction of chiral vicinal tertiary and quaternary centers by catalytic asymmetric 1,6-conjugate addition of prochiral carbon nucleophiles to cyclic dienones, Chem. Eur. J., 2015, 21, 18921-18924.

55. Kaihe Zou, Jinxing Ye*, Xin-Yan Wu*, Acid-catalyzed Efficient Friedel–Crafts reaction of indoles with N-Boc aminals, Tetrahedron, 2015, 71, 7869-7873.

54. Kaihe Zou, Jinxing Ye*, Xin-Yan Wu*, An efficient synthesis of styrenyl enamides from 4-aryl-2-oxazolidinones in the presence of strong base, Tetrahedron Lett., 2015, 56, 5517-5520.

53. Xiaodong Gu, Tingting Guo, Yuanyuan Dai, Allegra Franchino, Jie Fei, Chuncheng Zou, Darren J. Dixon*, Jinxing Ye*, Direct catalytic asymmetric doubly vinylogous michael addition of α,β-unsaturated γ-butyrolactams to dienones, Angew. Chem. Int. Ed., 2015, 54, 10249–10253.

52. Fei Wang, Na Zhu, Pinhong Chen, Jinxing Ye, Guosheng Liu*, Copper-catalyzed trifluoromethylazidation of alkynes: efficient access to CF3-substituted azirines and aziridines, Angew. Chem. Int. Ed., 2015, 54, 9356–9360.

51. Xinxin Wu, Chunna Meng, Xiaoqian Yuan, Xiaotong Jia, Xuhong Qian and Jinxing Ye*, Transition-metal-free visible-light photoredox catalysis at room-temperature for decarboxylative fluorination of aliphatic carboxylic acids by organic dyes, Chem. Commun., 2015, 51, 11864–11867.

50. Na Zhu, Fei Wang, Pinhong Chen, Jinxing Ye*, and Guosheng Liu, Copper-catalyzed intermolecular trifluoromethylazidation and trifluoromethylthiocyanation of allenes: efficient access to CF3-containing allyl azides and thiocyanates, Org. Lett., 2015, 17, 3580–3583.

49. Yuan Wei, Shigang Wen, Zunwu Liu, Xinxin Wu, Bubing Zeng, and Jinxing Ye*, Diastereodivergent catalytic asymmetric michael addition of 2-oxindoles to α,β-unsaturated ketones by chiral diamine catalysts, Org. Lett., 2015, 17, 2732–2735.

48. Haoxiang Hu, Chunna Meng, Yun Dong, Xin Li, and Jinxing Ye*, Catalytic asymmetric formal aza-diels–alder reactions of α,β-unsaturated ketones and 3H-indoles, ACS Catal., 2015, 5, 3700–3703.

47. Xiaodong Gu, Yuanyuan Dai, Tingting Guo, Allegra Franchino, Darren J. Dixon, and Jinxing Ye*, A general, scalable, organocatalytic nitro-Michael addition to enones: enantioselective access to all-carbon quaternary stereocenters, Org. Lett., 2015, 17, 1505-1508.

46. Xin Li, Min Lu, Yun Dong, Wenbin Wu, Qingqing Qian, Jinxing Ye* & Darren J Dixon*, Diastereodivergent organocatalytic asymmetric vinylogous Michael reactions, Nature Commun., 2014, 5, 4479.

45. Jiabin Xu, Xin Mu, Pinhong Chen, Jinxing Ye*, and Guosheng Liu*, Copper-catalyzed trifluoromethylthiolation of aryl halides with diverse directing groups, Org. Lett., 2014, 16, 3942–3945.

44. Junzhu Lu, Jinxing Ye, Wei-Liang Duan*, Palladium-catalyzed asymmetric 1,6-addition of diarylphosphines to alpha, beta, gamma, delta-unsaturated sulfonic esters: controlling regioselectivity by rational selection of electron-withdrawing groups, Chem. Commun., 2014, 50, 698-700.

43. Junzhu Lu, Jinxing Ye, Wei-Liang Duan*, Palladium-catalyzed asymmetric addition of diarylphosphines to alpha,beta-unsaturated sulfonic esters for the synthesis of chiral phosphine sulfonate compounds, Org. Lett., 2013, 15, 5016-5019.

42. Wenbin Wu, Xiaoqian Yuan, Juan Hu, Xinxin Wu, Yuan Wei, Zunwu Liu, Junzhu Lu, Jinxing Ye*, Catalytic asymmetric construction of chiral hydropyridazines via conjugate addition of N-monosubstituted hydrazones to enones, Org. Lett., 2013, 15, 4524–4527.

41. Huicai Huang, Wenbin Wu, Kailong Zhu, Juan Hu, Jinxing Ye*, Highly diastereo- and enantioselective cross-cascade reactions of different enones, Chem. Eur. J., 2013, 19, 3838-3841.

40. Kailong Zhu, Huicai Huang, Wenbin Wu, Yuan Wei, Jinxing Ye*, Aminocatalyzed asymmetric Diels–Alder reaction of 2,4-dienals and rhodanine/hydantoin derivatives, Chem. Commun., 2013, 49, 2157-2159.

39. Wenbin Wu, Xin Li, Huicai Huang, Xiaoqian Yuan, Junzhu Lu, Kailong Zhu, Jinxing Ye*, Asymmetric intramolecular oxa-Michael reactions of cyclohexadienones catalyzed by a primary amine salt, Angew. Chem. Int. Ed., 2013, 52, 1743–1747.

38. Wenbin Wu, Huicai Huang, Xiaoqian Yuan, Kailong Zhu, Jinxing Ye*, Asymmetric construction of spirocyclohexanonerhodanines catalyzed by simple diamine derived from chiral tert-leucine, Chem. Commun., 2012, 48, 9180–9182.

37. Feng Yu, Haoxiang Hu, Xiaodong Gu, Jinxing Ye*, Asymmetric Michael addition of substituted rhodanines to α,β-unsaturated ketones catalyzed by bulky primary amines, Org. Lett., 2012, 14, 2038–2041.

36. Huicai Huang, Kailong Zhu, Wenbin Wu, Zhichao Jin, Jinxing Ye*, Highly diastereoselective and enantioselective michael addition of 5h-oxazol-4-ones to α, β-unsaturated ketones catalyzed by a new bifunctional organocatalyst with broad substrate scope and applicability, Chem. Commun., 2012, 48, 461-463.

35. Xiaoyan Luo, Zhiqiang Zhou, Xin Li, Xinmiao Liang, Jinxing Ye*, Enantioselective organocatalytic phospha-michael reaction of α,β-unsaturated aldehydes, RSC Advances, 2011, 1, 698–705.  

34. Wenjun Li, Xin Li, Wenbin Wu, Xinmiao Liang, Jinxing Ye*, Highly diastereo- and enantioselective one-pot michael-aldol reactions of α, β-unsaturated aldehydes with imidazole derivatives, Chem. Commun., 2011, 47, 8325–8327.

33. Juanjuan Yang, Huicai Huang, Zhichao Jin, Wenbin Wu, Jinxing Ye*, Diastereoselective synthesis of bicyclo[2.2.2]octan-2-one derivatives through an unexpected organocatalytic tandem Michael-Michael reaction, Synthesis, 2011, 1984-1987.

32. Wenjun Li, Xin Li, Tingting Ye, Wenbin Wu, Xinmiao Liang, Jinxing Ye*, Asymmetric organocatalytic Michael/α-alkylation reaction of α, β-unsaturated aldehyde with chloroacetophenone, Tetrahedron Lett., 2011, 52, 2715-2718.

31. Xiaoyan Luo, Zhiqiang Zhou, Feng Yu, Xin Li, Xinmiao Liang, and Jinxing Ye*, Asymmetric vinylogous Michael reaction of α, β-unsaturated aldehyde with buteno-4-lactone, Chem. Lett., 2011, 40, 518-520.

30. Huicai Huang, Zhichao Jin, Kailong Zhu, Xinmiao Liang, Jinxing Ye*, Highly diastereo- and enantioselective synthesis of 5-substituted 3-pyrrolidin-2-ones through a direct vinylogous michael addition under multifunctional catalysis, Angew. Chem. Int. Ed., 2011, 50, 3232-3235.

29. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye*, Asymmetric direct michael addition of acetophenone to α, β-unsaturated aldehyde, Synthesis, 2011, 1085-1091.

28. Wenjun Li, Wenbin Wu, Feng Yu, Huicai Huang, Xinmiao Liang, Jinxing Ye*, Catalytic asymmetric michael addition with curcumin derivative, Org. Biomol. Chem., 2011, 9, 2505-2511.

27. Zhichao Jin, Xiao Wang, Huicai Huang, Xinmiao Liang, Jinxing Ye*, Diastereo- and enantioselective synthesis of oxazine and oxazolidine derivatives with chiral quaternary carbon center under multifunctional catalysis, Org. Lett., 2011, 13, 564-567.

26. Zhichao Jin, Huicai Huang, Wenjun Li, Xiaoyan Luo, Xinmiao Liang, Jinxing Ye*, Enantioselective organocatalytic synthesis of oxazolidine derivatives through a one-pot cascade reaction, Adv. Synth. Catal., 2011, 353, 343-348.

25. Zhichao Jin, Feng Yu, Xiao Wang, Huicai Huang, Xiaoyan Luo, Xinmiao Liang, Jinxing Ye*, A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives, Org. Biomol. Chem., 2011, 9, 1809-1816.

24. Xiaoyan Luo, Zhichao Jin, Pengfei Li, Jiabin Gao, Weimin Yue, Xinmiao Liang, Jinxing Ye*, Catalytic asymmetric michael addition of α, β-unsaturated aldehydes with ni(ii) complexes of the schiff base of glycine, Org. Biomol. Chem., 2011, 9 (3), 793-801.

23. Xiaomin Sun, Feng Yu, Tingting Ye, Xinmiao Liang, Jinxing Ye*, Catalytic asymmetric michael reaction of α, β-unsaturated ketones with sulfonyl containing nucleophiles: chiral synthesis of R-muscone and S-celery ketone, Chem. Eur. J., 2011, 17, 430-434.

22. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye*, Enantioselective michael reaction of α-alkyl-β-keto esters and enones under multifunctional catalysis, Org. Lett., 2010, 12, 5218-5221.

21. Feng Yu, Zhichao Jin, Huicai Huang, Tingting Ye, Xinmiao Liang, Jinxing Ye*, A highly efficient asymmetric Michael addition of α, α-disubstituted aldehydes to maleimides catalyzed by primary amine thiourea salt, Org. Biomol. Chem., 2010, 8, 4767-4774.

20. Yufeng Zhou, Xin Li, Wenjun Li, Chunlin Wu, Xinmiao Liang*, Jinxing Ye*, Asymmetric organocatalytic michael addition of α, β-unsaturated ketone with 1,2,4-triazole, Synlett, 2010, (15) , 2357-2360.

19. Huicai Huang, Feng Yu, Zhichao Jin, Wenjun Li, Wenbin Wu, Xinmiao Liang*, Jinxing Ye*, Asymmetric vinylogous Michael reaction of α, β-unsaturated ketones with γ-butenolide under multifunctional catalysis, Chem. Commun., 2010, 46, 5957-5959.

18. Feng Yu, Xiaomin Sun, Zhichao Jin, Shigang Wen, Xinmiao Liang*, Jinxing Ye*, Enantioselective michael addition of ketones to maleimides catalyzed by bifunctional monosulfonyl DPEN Salt, Chem. Commun., 2010, 46, 4589-4591.

17. Shigang Wen, Pengfei Li, Haibo Wu, Feng Yu, Xinmiao Liang*, Jinxing Ye*, Enantioselective organocatalytic phospha-Michael reaction of α, β-unsaturated ketones, Chem. Commun., 2010, 46, 4806-4808.

16. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang*, Jinxing Ye*, Asymmetric organocatalytic Michael addition of anthrone to enone, Org. Biomol. Chem., 2010, 8, 3244-3250.

15. Pengfei Li, Shigang Wen, Feng Yu, Qiaoxia Liu, Wenjun Li, Yongcan Wang, Xinmiao Liang*, Jinxing Ye*, Enantioselective organocatalytic Michael addition of malonates to α, β-unsaturated ketones, Org. Lett., 2009, 3, 753-756.

14. Pengfei Li, Yongcan Wang, Xinmiao Liang*, Jinxing Ye*, Asymmetric multifunctional organocatalytic Michael addition of nitroalkanes to α, β-unsaturated ketones, Chem. Commun., 2008, 3302-3304.

13. Yongcan Wang, Pengfei Li, Xinmiao Liang*, Jinxing Ye*, Base - Base bifunctional catalysis: a practical strategy for asymmetric Michael addition of malonates to α, β-unsaturated aldehydes, Adv. Synth. Catal., 2008, 350, 1383-1389.

12. Yongcan Wang, Pengfei Li, Xinmiao Liang*, Tony Y. Zhang, Jinxing Ye*, An efficient enantioselective method for asymmetric Michael addition of nitroalkanes to α, β-unsaturated aldehydes, Chem. Commun., 2008, 1232-1234.

11. Yongping Zhang, Zhimou Guo, Jinxing Ye, Qing Xu, Xinmiao Liang*, Aiwen Lei*, Preparation of novel β-cyclodextrin chiral stationary phase based on click chemistry, J. Chromatography A, 2008, 1191, 188-192.

10. Yongcan Wang, Jinxing Ye*, Xinmiao Liang*, Convenient preparation of chiral α, β-epoxyketones via claisen-schmidt condensation-epoxidation sequence, Adv. Synth. Catal., 2007, 349, 1033-1036.

9. A. L. Tillman, Jinxing Ye, D. J. Dixon*, Direct enantio- and diastereoselective Mannich reactions of malonate and beta-keto esters with N-Boc- and N-Cbz-aldimines catalysed by a bifunctional cinchonine derivative, Chem. Commun., 2006, 1191-1193.

8. Jinxing Ye, Darren J. Dixon*, Peter S. Hynes, Highly enantioselective Michael addition of malonate esters to nitro olefins using a cinchonine-derived bifunctional organic catalyst, Chem. Commun., 2005, 4481-4483.

7. Feifang Zhang, Jinxing Ye, Qing Zhang, Jiping Chen, Xinmiao Liang*, Enantioseparation of ranolazine using Shiseido chiral CD-PH column by RP-HPLC, Chin. J. Anal. Lab. (Chinese), 2005, 24(7), 48-50.

6. Yongcan Wang, Jinxing Ye, Xinmiao Liang*, Research on the epoxidation of enone under micellar condition, Chin. J. Org. Chem. (Chinese), 2005, 25(8), 969-971. (IF 1.318)

5. Jinxing Ye, Feifang Zhang, Qing Zhang, Jiping Chen, Xinmiao Liang*, Chiral separation of β-blocking agents by RP-HPLC, J. Instru. Anal. (Chinese), 2004, 23, 80-82.

4. Jinxing Ye, Yongcan Wang, Jiping Chen, Xinmiao Liang*, Trichloroisocyanuric acid: a convenient oxidation reagent for phase-transfer catalytic epoxidation of enones under non-aqueous conditions, Adv. Synth. Catal., 2004, 346, 691-696.

3. Jinxing Ye, Yongcan Wang, Renhua Liu, Guofu Zhang, Qing Zhang, Jiping Chen, Xinmiao Liang*, A highly enantioselective phase-transfer catalyzed epoxidation of enones with a mild oxidant of trichloroisocyanuric acid, Chem. Commun., 2003, 2714–2715.

2. Jiehan Hu*, Jinxing Ye, Guobao Cheng, Xiangyun Long, Quantum chemistry ab initio calculation of vibration spectrum of β-elemene, Spectrosc. Spect. Anal. (Chinese), 2001, 21, 163-168.

1. Jinxing Ye, Guobao Cheng, Jiehan Hu*, Study on computational chemistry of elemene and its derivatives: ι. theoretical calculation of 13C NMR chemical shifts of β-elemene, Chin. J. Mag. Reson. (Chinese), 2000, 17, 115-120.


所获荣誉

2004年,The Royal Society Postdoctoral Fellowship

2008年,入选上海市“浦江人才计划”

2009-2011年,华东理工大学校优秀教育工作者

2011和2018年,华东理工大学,两次“天鼎-东岳”研究生奖教金一等奖

2011年,指导1名博士和3名硕士获得华东理工大学优秀研究生论文,其中2人获得上海市优秀研究生成果(论文)

2012年,获得国际奖励Thieme Chemistry Journal Award

2012年,指导本科生参加第七届上海市大学生创业计划大赛决赛,荣获铜奖

2013年,入选教育部新世纪优秀人才支持计划

2018年,入选江苏省双创人才计划

2019年,华东理工大学第五届“良师益友”我心中的好导师提名奖

2007年-至今,指导的研究生获得过华东理工大学国家奖学金、博禄奖学金、BASF奖学金、天鼎-东岳奖学金特等奖、天鼎-东岳奖学金一等奖等超过20人次


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