所属学院：生物医药学院

导师类别：硕士生导师

职务： 无

科研方向：神经退行性疾病（老年痴呆症和帕金森综合征）的发病机制研究及药物开发

Email： wuxiaoli@gdut.edu.cn;  

招生学院：生物医药学院

个人简述：

吴晓丽，女，博士，硕士研究生导师。广东工业大学“青年百人计划”引进人才。主持国家自然科学资金-青年资金一项，广东省教育厅青年创新人才项目一项和中国博士后科学资金面上项目一等资助。以第一作者或通讯作者在Neuropharmacology，ACS Chemical Neuroscience，European Journal of Pharmaceutical Sciences和Food & Function等杂志上发表论文10余篇。

 

学科领域

科学学位：制药工程

专业学位：材料与化工（生物医药方向）

教育背景

08/2014-09/2017  澳门大学健康科学学院      生物医药        哲学博士

09/2011-06/2014  广州中医药大学中药学院    中药学          医学硕士

09/2007-06/2011  广州中医药大学中药学院    中药资源与开发  理学学士

工作经历

2020.05-至今     广东工业大学生物医药学院      讲师 

2017/10-2020/04  广州中医药大学第二附属医院    脑病中心  博士后 

科研项目

1. 国家自然科学基金青年基金，基于TREM2-DAP12通路调控小胶质细胞Aβ吞噬研究姜黄素氢化物改善阿尔兹海默病的作用及机制（82003615），2021/01-2023/12，24万元，在研，主持。

2. 广东省教育厅“青年创新人才”项目，姜黄素活性代谢产物通过NF-κB-NLRP3炎症小体/STAT6-PPARγ调控小胶质细胞极化改善阿尔茨海默病作用及机制（2019KQNCX024），2020/01-2021/12，5万元，在研，主持。

3. 第63批中国博士后科学基金面上一等资助，2018M630942，丹参酮IIA靶向ET-1抗缺血性脑损伤的内源性干细胞修复的机制研究，2017/10-2019/10，8万元，结题，主持。

发表论文

[1] Li CW*, Deng MZ, Gao ZJ, Dang YY, Zheng GD, Yang XJ, Chao YX, Cai YF, Wu XL*, Effects of compound K, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involves inhibition of ER stress and NLRP3 inflammasome pathway[J], Food & Function, 2020, 11(5): 4416-4427.

[2] Wu XL, Deng MZ, Gao ZJ, Dang YY, Li YC, Li CW*, Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress[J], International Immunopharmacology, 2020, 84:106559, DOI:10.1016/j.intimp.2020.106559.

[3] Wu XL*, Tang BQ, Liao X, Su ZR, Lee SM, Cai YF, Li CW*, Suppressive effects of the supercritical-carbon dioxide fluid extract of Chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice[J], Food & Function, 2019, 10(2):1212-1224.

[4] Wu XL^#, Kosaraju J^#, Zhou W, Tam KY*, SLOH, a carbazole-based fluorophore, mitigates neuropathology and behavioral impairment in the triple-transgenic mouse model of Alzheimer's disease[J], Neuropharmacology, 2018, 131:351-363.

[5] Wu XL, Kosaraju J, Tam KY*, Anti-neuroinflammatory effects of SLOH in Aβ-induced BV-2 microglial cells and 3xTg-AD mice involve the inhibition of GSK-3β[J], Neuroscience Letters, 2018, 687:207-215.

[6] Wu XL^#, Kosaraju J^#, Zhou W, Tam KY*, Neuroprotective Effect of SLM, a Novel Carbazole-Based Fluorophore, on SH-SY5Y Cell Model and 3xTg-AD Mouse Model of Alzheimer’s Disease[J], ACS Chemical Neuroscience, 2017, 8(3):676-685.

[7]Wu XL, Kosaraju J, Tam KY*, SLM, a novel carbazole-based fluorophore attenuates okadaic acid-induced tau hyperphosphorylation via down-regulating GSK-3β activity in SH-SY5Y cells[J], European Journal of Pharmaceutical Sciences, 2017, 110:101-108.

[8] Wu XL, Li J, Zhou W, Tam KY*, Animal models for Alzheimer's disease: A focused review of transgenic rodent models and behavioral assessment methods[J], ADMET and DMPK, 2015, 3(3):242-253.

[9] Wu XL^#, Feng XX^#, Li CW, Zhang XJ, Chen ZW, Chen JN, Lai XP, Zhang SX, Li YC*, Su ZR*, The protective effects of the supercritical-carbon dioxide fluid extract of chrysanthemum indicum against lipopolysaccharide-induced acute lung injury in mice via modulating toll-like receptor 4 signaling pathway[J], Mediators of Inflammation, 2014: 246407.

[10] Wu XL^#, Li CW^#, Chen HM, Su ZQ, Zhao XN, Chen JN, Lai XP, Zhang XJ*, Su ZR*, Anti-inflammatory effect of supercritical-carbon dioxide fluid extract from flowers and buds of Chrysanthemum indicum Linnén[J], Evidence-based Complementary and Alternative Medicine, 2013: 413237.

[11] Li CW^#, Chen ZW^#, Wu XL^#, Zhao XN, Su ZQ, Li YC, Su ZR*, Lai XP*, A standardized traditional Chinese medicine preparation named yejuhua capsule ameliorates lipopolysaccharide-induced acute lung injury in mice via downregulating toll-like receptor 4/nuclear factor-κB[J], Evidence-based Complementary and Alternative Medicine, 2015: 264612.

[12] Li CW^#, Wu XL^#, Zhao XN, Su ZQ, Chen HM, Wang XF, Zhang XJ*, Zeng HF*, Chen JN, Li YC, Su ZR, Anti-inflammatory property of the ethanol extract of the root and rhizome of Pogostemon cablin (Blanco) benth[J], The Scientific World Journal, 2013: 434151.

[13] Su ZQ^#, Wu XL^#, Bao MJ, Li CW, Kong SZ, Su ZR, Lai XP, Li YC*, Chen JN*, Isolation of (-)-patchouli alcohol from patchouli oil by fractional distillation and crystallization[J], Tropical Journal of Pharmaceutical Research, 2014, 13(3):359-363.