黎相广 XIANGGUANG LI 副教授

所属学院：生物医药学院

导师类别：硕士生导师

科研方向：干细胞与肠类器官芯片、天然活性成分与肠道健康

联系方式：xgli@gdut.edu.cn

硕士招生学院：生物医药学院

课题组：制药工程系

个人简述：

黎相广，男，博士，副教授，硕士生导师。曾公派到美国俄亥俄州立大学Wexner医学中心联合培养博士，主要从事干细胞与肠类器官芯片、天然活性成分与肠道健康的研究工作。主持国家自然科学基金项目2项、广东省基础与应用基础研究基金项目3项、广东省药品监督管理局科技项目引导扶持专项1项。承担《药理学》《药物筛选与成药性评价》《微生物学与免疫学》《生物技术制药》《现代生物制药技术》《干细胞工程与肠道健康》等课程的教学工作。

教育背景：

2016.12–2017.12：美国俄亥俄州立大学Wexner医学中心（访问学者）

2014.09–2017.06：华南农业大学动物营养专业（博士）

工作经历：

2018.01–至今：广东工业大学，生物医药学院，讲师、副教授

2021.03–2021.12：国家自然科学基金委员会，兼聘

主要论文：

1. Jinhua He, Geng Zhao, Mingxia Chen, Ximing Ren, Peizhi Zhu, Zhizhong Liu, Jiayi Zhou , Hanwei Chen, Chuqiao Xiao*, Xiang-Guang Li*. Identification and functional analysis of hub genes involved in deoxynivalenol-induced enterotoxicity in porcine (Sus scrofa). Ecotoxicology and Environmental Safety, 2025, 290: 117544.

2. Chuqiao Xiao, Ruibo Jia, Xiang-Guang Li*, Mouming Zhao*, Wenzhen Liao, Suqing Zhao, Feiran Xu, Fidel Toldrá. Musculus senhousei peptides alleviated alcoholic liver injury via the gut–liver axis. Food & Function, 2024, 15(13):7124-7135.

3. Min Zhu, En-qing Lu, Ling Yan, Guowei Liu, Ke Huang, E Xu, Yi-yu Zhang*, Xiang-Guang Li*. Phospholipase D mediates glutamine-induced mTORC1 activation to promote porcine intestinal epithelial cell proliferation. Journal of Nutrition, 2024,154(4): 1119-1129.

4. Fangqian Yu, Yutong Du, Cong Li, Haiyan Zhang, Weiming Lai, Sheng Li, Zhenhao Ye, Wenbin Fu, Shumin Li, Xiang‑Guang Li*, Ding Luo*. Association between metabolites in tryptophan‑kynurenine pathway and inflammatory bowel disease: a two‑sample Mendelian randomization. Scientific Reports, 2024, 14: 201.

5. Min Zhu, Weiming Lai, Lewen Yao, E Xu, Xiang Chen, Yi-yu Zhang*, Xiang-Guang Li*. Glutamine regulates gene expression profiles to increase the proliferation of porcine intestinal epithelial cells and the expansion of intestinal stem cells. Animals, 2023, 13(18): 2917.

6. Weiming Lai, Changxiu Xian, Mingxia Chen, Ding Luo, Junxia Zheng, Suqing Zhao, Xiang-Guang Li*. Single-cell and bulk transcriptomics reveals M2d macrophages as a potential therapeutic strategy for mucosal healing in ulcerative colitis. International Immunopharmacology, 2023, 121: 110509.

7. Changxiu Xian, Jiaxin Zhang, Suqing Zhao, Xiang-Guang Li*. Gut-on-a-chip for disease models. Journal of Tissue Engineering. 2023, 14: 1149882.

8. Weiming Lai, Ziheng Huang, Sheng Li, Xiang-Guang Li*, Ding Luo*. Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response. International Immunopharmacology, 2023, 117: 109840.

9. Ying‑chao Qin, Jia‑yi Zhou, Min Zhu, Geng‑xiu Zan, Chun‑qi Gao, Hui‑chao Yan, Xiang‑Guang Li*, Xiu‑qi Wang*. L‑glutamate requires β‑catenin signalling through Frizzled7 to stimulate porcine intestinal stem cell expansion. Cellular and Molecular Life Sciences. 2022, 79(10): 523.

10. Xiang-Guang Li, Ming-Xia Chen, Su-Qing Zhao*, Xiu-Qi Wang*. Intestinal models for personalized medicine: from conventional models to microfluidic primary intestine-on-a-chip. Stem Cell Reviews and Reports. 2022, 18(6): 2137–2151.

11. Tian-Tian Wang, Xiang-Guang Li*, Li-Li Chen, You-Huan Zhang, Yu-Jun Zheng, Lin-Jin Yu, Zhi-Yu Ye, Hua-Qian Wang, Xi-Ping Cui, Su-Qing Zhao*. The preparation of bifunctional hybrid nano-flowers and their application in the enzyme-linked immunosorbent assay for Helicobacter pylori detection. Analyst. 2021, 146(1):338-347.

12. Xiang-Guang Li, Pan He, Lin-Jin Yu, Qi-Yi He, Cheng-Gang Jia, Hui-Yi Yang, Ming-Lei Lu, Xiu-Ting Wei, Su-Qing Zhao*. Production and characteristics of a novel chicken egg yolk antibody (IgY) against periodontitis-associated pathogens. Journal of Oral Microbiology. 2020, 12(1):1831374.

13. Jia‐Yi Zhou, Deng‐Gui Huang, Min Zhu, Chun‐Qi Gao, Hui‐Chao Yan, Xiang-Guang Li*, Xiu-Qi Wang*. Wnt/β‐catenin‐mediated heat exposure inhibits intestinal epithelial cell proliferation and stem cell expansion through endoplasmic reticulum stress. Journal of Cellular Physiology. 2020, 235(7-8): 5613-5627.

14. Min Zhu, Ying-Chao Qin, Chun-Qi Gao, Hui-Chao Yan, Xiang-Guang Li*, Xiu-qi Wang*. Extracellular glutamate-induced mTORC1 activation via the IR/IRS/PI3K/Akt pathway enhances the expansion of porcine intestinal stem cells. Journal of Agricultural and Food Chemistry. 2019, 67(34): 9510-9521.

15. Li-Li Chen, Xiang-Guang Li*, Tong-Da Zou, Tian-Tian Wang, Xi-Ping Cui, Ying-Shan Chen, Chun-Guo Zhang, Su-Qing Zhao*. Ultrasensitive detection of H. pylori in human feces based on immunomagnetic bead capture and fluorescent quantum dots. Analyst. 2019, 144(13): 4086-4092.

16. Xiang-Guang Li, Min Zhu, Ming-Xia Chen, Hong-Bo Fan, Hou-Long Fu, Jia-Yi Zhou, Zhen-Ya Zhai, Chun-Qi Gao, Hui-Chao Yan, Xiu-Qi Wang*. Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/beta-catenin pathway. Toxicology Letters. 2019, 305: 19-31.

17. Xiang-Guang Li, Zhe Wang, Rong-Qiang Chen, Hou-Long Fu, Chun-Qi Gao, Hui-Chao Yan, Guang-Xu Xing, Xiu-Qi Wang*. LGR5 and BMI1 increase pig intestinal epithelial cell proliferation by stimulating WNT/beta-catenin signaling. International Journal of Molecular Sciences. 2018, 19(4): 1036.

18. Xiang-Guang Li, Wei-Guo Sui, Chun-Qi Gao, Hui-Chao Yan, Yu-Long Yin, Hai-Chang Li, Xiu-Qi Wang*. L-Glutamate deficiency can trigger proliferation inhibition via down regulation of the mTOR/S6K1 pathway in pig intestinal epithelial cells. Journal of Animal Science. 2016, 94(4):1541-1549.

19. Xiang-Guang Li, Wei-Guo Sui, Hui-Chao Yan, Qing-Yan Jiang, Xiu-Qi Wang*. The in ovo administration of L-trans pyrrolidine-2,4-dicarboxylic acid regulates small intestinal growth in chicks. Animal. 2014, 8(10): 1677-1683.

20. Xiang-Guang Li, Xue-Ling Chen, Xiu-Qi Wang*. Changes in relative organ weights and intestinal transporter gene expression in embryos from White Plymouth Rock and WENS Yellow Feather Chickens. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 2013, 164(2): 368-375.

主持的科研项目：

1. 国家自然科学基金面上项目：基于干细胞三维培养技术的猪肠道类器官芯片的构建及仿生性能评价新方法

2. 国家自然科学基金青年项目：石榴皮鞣质调控“肠道干细胞-杯状细胞-MUC2”轴缓解ETEC感染仔猪肠黏膜损伤的机制研究

3. 广东省基础与应用基础研究基金优秀青年项目：基于肠芯片的产肠毒素大肠杆菌损伤猪肠黏膜的细胞异质性及分子网络研究

4. 广东省基础与应用基础研究基金面上项目：安石榴苷靶向Frizzled调控肠道干细胞命运抗ETEC损伤的机制研究

5. 广东省基础与应用基础研究基金青年项目：乳脂肪球膜蛋白质调控肠道干细胞参与ETEC腹泻仔猪肠黏膜修复的机制研究

6. 广东省药品监督管理局科技项目引导扶持专项：中药有害物质免疫检测方法及降解技术研究

7. 广东工业大学“青年百人计划”科研启动项目：肠道致病菌卵黄抗体的制备