黎相广 XIANGGUANG LI 副教授

所属学院：生物医药学院

导师类别：硕士生导师

科研方向：干细胞与肠类器官芯片、天然活性成分与肠道健康

联系方式：xgli@gdut.edu.cn

硕士招生学院：生物医药学院

课题组：制药工程系

职务：院长助理

个人简述：

黎相广，男，博士，副教授，硕士生导师。曾公派到美国俄亥俄州立大学Wexner医学中心联合培养博士，目前担任广东省生物医学工程学会药品食品智能制造工程分会委员和广东省药理学会内分泌代谢病药理专业委员会委员，主要从事干细胞与肠类器官芯片、天然活性成分与肠道健康的研究工作。主持国家自然科学基金青年基金项目、广东省基础与应用基础研究基金面上基金、广东省基础与应用基础研究基金区域联合基金-青年基金项目、广东省药品监督管理局科技项目引导扶持专项、广东工业大学“青年百人计划”科研启动项目等，发表SCI论文32篇。承担《药理学》《药物筛选与成药性评价》《微生物学与免疫学》《生物技术制药概论》《药食同源与健康》《宠物营养与饲料》等课程的教学工作。

教育背景：

2016.12–2017.12：美国俄亥俄州立大学Wexner医学中心（访问学者）

2014.09–2017.06：华南农业大学动物营养专业（博士）

工作经历：

2018.01–至今：广东工业大学，生物医药学院，讲师、副教授

2021.03–2021.12：国家自然科学基金委员会，兼聘

社会兼职：

广东省生物医学工程学会药品食品智能制造工程分会委员

广东省药理学会内分泌代谢病药理专业委员会委员

主要论文：

1. Changxiu Xian, Jiaxin Zhang, Suqing Zhao, Xiang-Guang Li*. Gut-on-a-chip for disease models. Journal of Tissue Engineering. 2023, 14: 1149882.

2. Weiming Lai, Ziheng Huang, Sheng Li, Xiang-Guang Li*, Ding Luo*. Kynurenine pathway metabolites modulated the comorbidity of IBD and depressive symptoms through the immune response. International Immunopharmacology, 2023, 117: 109840.

3. Qinglan Li, Li Ji, Beibei Jiang, Xiang-Guang Li, Zhaoji Lv, Jinpo Xie, Siping Chen, Kailin Xu*, Yingwei Yang*, Suqing Zhao*. Pillararene-functionalized rhodium nanoparticles for efficient catalytic reduction and photothermal sterilization. Chemical Communications, 2022,58, 13079-13082.

4. Chuanlong Wang, Yahong Jin*, Jiaxin Zhang, Xiang-Guang Li, Haoyi Wu, Ruiting Zhang, Qing Yao, Yihua Hu*. Linear charging-discharging of an ultralong UVA persistent phosphor for advanced optical data storage and wide-wavelength-range detector. Chemical Engineering Journal. 2022: 139558.

5. Ying‑chao Qin, Jia‑yi Zhou, Min Zhu, Geng‑xiu Zan, Chun‑qi Gao, Hui‑chao Yan, Xiang‑Guang Li*, Xiu‑qi Wang*. L‑glutamate requires β‑catenin signalling through Frizzled7 to stimulate porcine intestinal stem cell expansion. Cellular and Molecular Life Sciences. 2022, 79(10): 523.

6. Xiang-Guang Li, Ming-Xia Chen, Su-Qing Zhao*, Xiu-Qi Wang*. Intestinal models for personalized medicine: from conventional models to microfluidic primary intestine-on-a-chip. Stem Cell Reviews and Reports. 2022, 18(6): 2137–2151.

7. Shan Liang, Li Ji, Yingying Zhong, Tiantian Wang, Huiyi Yang, Qing-Lan Li*, Xiang-Guang Li*, Suqing Zhao*. Fluorescence immunoassay for the targeted determination of trace Listeria monocytogenes based on immunomagnetic separation and CdZnTe quantum dot indication. Analytical Methods. 2022, 14(11): 1124-1133.

8. Haichang Li#*, Pei‑Hui Lin#, Pranav Gupta, Xiang-Guang Li, Serena Li Zhao, Xinyu Zhou, Zhongguang Li, Shengcai Wei, Li Xu, Renzhi Han, Jing Lu, Tao Tan, Dong‑Hua Yang, Zhe‑Sheng Chen, Timothy M. Pawlik, Robert E. Merritt, Jianjie Ma*. MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer. Molecular Cancer. 2021, 20(1): 118.

9. Jia-Yi Zhou, Hua-Lin Lin, Ying-Chao Qin, Xiang-Guang Li, Chun-Qi Gao, Hui-Chao Yan, Xiu-qi Wang*. L-Carnosine protects against deoxynivalenol-induced oxidative stress in intestinal stem cells by regulating the Keap1/Nrf2 signaling pathway. Molecular Nutrition & Food Research. 2021,65(17): 2100406.

10. Tian-Tian Wang, Xiang-Guang Li*, Li-Li Chen, You-Huan Zhang, Yu-Jun Zheng, Lin-Jin Yu, Zhi-Yu Ye, Hua-Qian Wang, Xi-Ping Cui, Su-Qing Zhao*. The preparation of bifunctional hybrid nano-flowers and their application in the enzyme-linked immunosorbent assay for Helicobacter pylori detection. Analyst. 2021, 146(1):338-347.

11. Xiang-Guang Li, Pan He, Lin-Jin Yu, Qi-Yi He, Cheng-Gang Jia, Hui-Yi Yang, Ming-Lei Lu, Xiu-Ting Wei, Su-Qing Zhao*. Production and characteristics of a novel chicken egg yolk antibody (IgY) against periodontitis-associated pathogens. Journal of Oral Microbiology. 2020, 12(1):1831374.

12. Hua-Feng He, Dan-Min Lin, Jia-Jie Sun, Xian-Ying He, Tian-Tian Wang, Ying-Lin Fang, Yi-Jun Liu, Kai-Xiang Fan, Xin-Xin Chen, Hua-Hong He, Xiang-Guang Li, Bian-Sheng Ji, Su-Qing Zhao, Xi Zheng, Kun Zhang, Hua-Qian Wang*. An in vitro and in vivo study of the brain-targeting effects of an epidermal growth factor-functionalized cholera toxin-like chimeric protein. Journal of Controlled Release. 2020, 322: 509-518.

13. Jia‐Yi Zhou, Deng‐Gui Huang, Min Zhu, Chun‐Qi Gao, Hui‐Chao Yan, Xiang-Guang Li*, Xiu-Qi Wang*. Wnt/β‐catenin‐mediated heat exposure inhibits intestinal epithelial cell proliferation and stem cell expansion through endoplasmic reticulum stress. Journal of Cellular Physiology. 2020, 235(7-8): 5613-5627.

14. Min Zhu, Ying-Chao Qin, Chun-Qi Gao, Hui-Chao Yan, Xiang-Guang Li*, Xiu-qi Wang*. Extracellular glutamate-induced mTORC1 activation via the IR/IRS/PI3K/Akt pathway enhances the expansion of porcine intestinal stem cells. Journal of Agricultural and Food Chemistry. 2019, 67(34): 9510-9521.

15. Li-Li Chen, Xiang-Guang Li*, Tong-Da Zou, Tian-Tian Wang, Xi-Ping Cui, Ying-Shan Chen, Chun-Guo Zhang, Su-Qing Zhao*. Ultrasensitive detection of H. pylori in human feces based on immunomagnetic bead capture and fluorescent quantum dots. Analyst. 2019, 144(13): 4086-4092.

16. Yingying Zhong, Qing-lan Li, Minglei Lu, Tiantian Wang, Huiyi Yang, Qiyi He, Xiping Cui*, Xiang-Guang Li*, Suqing Zhao*. A colorimetric sensing strategy based on enzyme@metal-organic framework and oxidase-like IrO₂/MnO² nanocomposite for α-glucosidase inhibitor screening. Microchimica Acta. 2020,187(12): 675.

17. Shao-Jie Liang, Xiang-Guang Li, Xiu-Qi Wang*. Notch signaling in mammalian intestinal stem cells: determining cell fate and maintaining homeostasis. Current Stem Cell Research & Therapy. 2019, 14(7): 583-590.

18. Jia-Yi Zhou, Deng-Gui Huang, Ying-Chao Qin, Xiang-Guang Li, Chun-Qi Gao, Hui-Chao Yan, Xiu-Qi Wang*. mTORC1 signaling activation increases intestinal stem cell activity and promotes epithelial cell proliferation. Journal of Cellular Physiology. 2019, 234(10): 19028-19038.

19. Xiang-Guang Li, Min Zhu, Ming-Xia Chen, Hong-Bo Fan, Hou-Long Fu, Jia-Yi Zhou, Zhen-Ya Zhai, Chun-Qi Gao, Hui-Chao Yan, Xiu-Qi Wang*. Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/beta-catenin pathway. Toxicology Letters. 2019, 305: 19-31.

20. Xiang-Guang Li, Zhe Wang, Rong-Qiang Chen, Hou-Long Fu, Chun-Qi Gao, Hui-Chao Yan, Guang-Xu Xing, Xiu-Qi Wang*. LGR5 and BMI1 increase pig intestinal epithelial cell proliferation by stimulating WNT/beta-catenin signaling. International Journal of Molecular Sciences. 2018, 19(4): 1036.

21. Hong-Bo Fan, Zhen-Ya Zhai, Xiang-Guang Li, Chun-Qi Gao, Hui-Chao Yan, Zhe-Sheng Chen, Xiu-Qi Wang*. CDX2 stimulates the proliferation of porcine intestinal epithelial cells by activating the mTORC1 and Wnt/β-catenin signaling pathways. International Journal of Molecular Sciences. 2017, 18(11): 2447.

22. Mi Li #, Haichang Li #, Xiang-Guang Li, Hua Zhu, Zihui Xu, Lianqing Liu*, Jianjie Ma*, Mingjun Zhang*. A bioinspired alginate-gum arabic hydrogel with micro-/nanoscale structures for controlled drug release in chronic wound healing. ACS Applied Materials & Interfaces. 2017, 9 (27): 22160-22175.

23. Jing-E Ma, Qian-Qian Lang, Feng-Fang Qiu, Li Zhang, Xiang-Guang Li, Wen Luo, Juan Wang, Xing Wang, Xi-Ran Lin, Wen-Sheng Liu, Qing-Hua Nie, Xi-Quan Zhang*. Negative glucocorticoid response-like element from the first intron of the chicken growth hormone gene represses gene expression in the rat pituitary tumor cell line. International Journal of Molecular Sciences. 2016, 17(11): E 1863.

24. Jin-Ling Ye #, Chun-Qi Gao #, Xiang-Guang Li #, Cheng-Long Jin, Dan Wang, Gang Shu, Wen-Ce Wang, Xiang-Feng Kong, Kang Yao, Hui-Chao Yan, Xiu-Qi Wang*. EAAT3 promotes amino acid transport and proliferation of porcine intestinal epithelial cells. Oncotarget. 2016, 7(25): 38681-38692.

25. Ming-Xia Chen #, Xiang-Guang Li #, Hui-Chao Yan, Xiu-Qi Wang*, Chun-Qi Gao*. Effect of egg weight on composition, embryonic growth, and expression of amino acid transporter genes in yolk sac membranes and small intestines of the domestic pigeon (Columba livia). Poultry Science. 2016, 95(6):1425-1432.

26. Xiang-Guang Li, Gao-Feng Xu, Zhen-Ya Zhai, Chun-Qi Gao, Hui-Chao Yan, Qian-Yun Xi, Wu-Tai Guan, Song-Bo Wang, Xiu-Qi Wang*. CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget. 2016, 7(21): 30597–30609.

27. Xiang-Guang Li, Wei-Guo Sui, Chun-Qi Gao, Hui-Chao Yan, Yu-Long Yin, Hai-Chang Li, Xiu-Qi Wang*. L-Glutamate deficiency can trigger proliferation inhibition via down regulation of the mTOR/S6K1 pathway in pig intestinal epithelial cells. Journal of Animal Science. 2016, 94(4):1541-1549.

28. Ming-Xia Chen #, Xiang-Guang Li #, Jun-Xian Yang, Chun-Qi Gao, Bin Wang, Xiu-Qi Wang*, Hui-chao Yan*. The growth of embryo and gene expression of nutrient transporters in the small intestine of domestic pigeon (Columba livia). Journal of Zhejiang University-SCIENCE B. 2015, 16(6): 511-523.

29. Li-Na Wang #, Xue-Ling Chen #, Xiang-Guang Li, Gang Shu, Hui-Chao Yan, Xiu-Qi Wang*. Evaluation of adrenocorticotropin regulated glucocorticoid synthesis pathway in adrenal of different breeds of pigs. Livestock Science. 2014, 169: 185–191.

30. Xiang-Guang Li, Wei-Guo Sui, Hui-Chao Yan, Qing-Yan Jiang, Xiu-Qi Wang*. The in ovo administration of L-trans pyrrolidine-2,4-dicarboxylic acid regulates small intestinal growth in chicks. Animal. 2014, 8(10): 1677-1683.

31. Xiang-Guang Li, Xue-Ling Chen, Xiu-Qi Wang*. Changes in relative organ weights and intestinal transporter gene expression in embryos from White Plymouth Rock and WENS Yellow Feather Chickens. Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 2013, 164(2): 368-375.

32.Pei-Ling Zeng #, Xiang-Guang Li #, Xiu-Qi Wang*, De-Xiang Zhang, Gang Shu, Qing-Bin Luo. The relationship between gene expression of cationic and neutral amino acid transporters in the small intestine of chick embryos and chick breed, development, sex, and egg amino acid concentration. Poultry Science. 2011, 90(11): 2548-2556.

主持的科研项目：

1. 广东省基础与应用基础研究基金面上项目：安石榴苷靶向Frizzled调控肠道干细胞命运抗ETEC损伤的机制研究

2. 广东省药品监督管理局科技项目引导扶持专项：中药有害物质免疫检测方法及降解技术研究

3. 国家自然科学基金青年基金项目：石榴皮鞣质调控“肠道干细胞-杯状细胞-MUC2”轴缓解ETEC感染仔猪肠黏膜损伤的机制研究

4. 广东省基础与应用基础研究基金区域联合基金-青年基金项目：乳脂肪球膜蛋白质调控肠道干细胞参与ETEC腹泻仔猪肠黏膜修复的机制研究

5. 广东工业大学“青年百人计划”科研启动项目：肠道致病菌卵黄抗体的制备