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孙晓鸥 副教授

发布日期:2019-01-11    作者:     来源:     点击:

孙晓鸥 XIAOOU SUN 副教授

所属学院:生物医药学院

导师类别:硕士生导师

科研方向:心脑血管疾病和治疗机制研究

联系地址:E-mail:xiaoousun@gdut.edu.cn

个人简介

孙晓鸥,辽宁人,博士毕业于南开大学生命科学学院遗传学与细胞生物学专业,主要从事微管相关蛋白在细胞活动及相关疾病中的功能和分子机制研究,期间参与973计划“调控细胞增殖与细胞凋亡的分子机制研究”、国家自然基金重点项目“微管结合蛋白EB1磷酸化的调控及功能研究”和国家自然基金重大研究计划“基于化学小分子的细胞增殖信号通路和肿瘤发病机制研究及其在肿瘤治疗上的应用”等项目,研究结果分别发表在The Journal of Biological Chemistry、The Journal of Pathology、Cell Cycle、Theranostics、Plos One等杂志上。毕业后在美国Emory大学病理学与实验药学专业进行博士后培养,主要从事于溶酶体酶AEP的转录调控以及AEP酶作用于其底物蛋白在脑卒中和神经退行性疾病中的生物学功能和相关分子机制的研究。自2014年回国以来,致力于心脑血管疾病的致病机制的研究,在相关领域顶级医学期刊上发表综述文章1篇,已发表论文30余篇(SCI论文20余篇),近四年以第一作者/通讯作者身份发表论文SCI论文16主持5项课题研究。

教育背景

2003.9-2007.6 南开大学生命科学学院,生物科学专业(本科)

2007.9-2012.6 南开大学生命科学学院,遗传学与细胞生物学专业(硕博连读)

2012.10-2013.10 美国艾默里(Emory)大学,病理学与实验药学专业,博士后

工作经历

2014.10-2017.10 华南理工大学生物科学与工程学院,讲师

2017.10至今 广东工业大学副教授

荣誉奖励

1.华南理工大学,2015年指导本科生国际遗传工程机器大赛(iGEM)团队获得金奖

2.华南理工大学,青年教师本科课堂教学竞赛,鼓励奖

科研领域

目前主要从事细胞生物学、分子生物学与生物化学等领域的教学与科研工作。研究方向集中于心脑血管疾病方向。

主要论文

1.Zhang H#, Liu Y, Li M, Peng G, Zhu T,Sun X*. The Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Modulate the Progression of Cerebral Ischemia/Reperfusion Injury.Mol Neurobiol.2022 Feb; 59(2):1073-1087.

2.Liu F#, Song L, Lu Z, Sun T, Lun Z, Zhou C,Sun X*, Tan W*, Zhao H*. Isosteviol improves cardiac function and promotes angiogenesis after myocardial infarction in rats.Cell Tissue Res.2022 Feb; 387(2):275-285.

3.Zhang H#, Li M, Liang J, Li M,Sun X*. Long Non-coding RNA PVT1 Inhibits miR-30c-5p to Upregulate Rock2 to Modulate Cerebral Ischemia/Reperfusion Injury Through MAPK Signaling Pathway Activation.Mol Neurobiol.2021 Nov; 58(11):6032-6048.

4.Ke Q#, Liu F, Tang Y, Chen J, Hu H,Sun X*, Tan W*.The protective effect of isosteviol sodium on cardiac function and myocardial remodelling in transverse aortic constriction rat.J Cell Mol Med.2021 Jan; 25(2):1166-1177.

5.Zhang H#, Liu B, Shi X*,Sun X*.Long noncoding RNAs: Potential therapeutic targets in cardiocerebrovascular diseases.Pharmacol Ther.2021 May; 221:107744.

6.Mei Y#, Liu B, Su H, Zhang H, Liu F, Ke Q,Sun X*, Tan W. Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC-1α pathway.J Cell Mol Med.2020 Sep; 24(18):10866-10875.

7.Liu F#, Su H, Liu B, Mei Y, Ke Q,Sun X*, Tan W*.STVNa Attenuates Isoproterenol-Induced Cardiac Hypertrophy Response through the HDAC4 and Prdx2/ROS/Trx1 Pathways.Int J Mol Sci.2020 Jan 20;21(2). pii: E682.

8.Zeng J, Zhu L, Liu J, Zhu T, Xie Z*,Sun X*, Zhang H*.Metformin Protects against Oxidative Stress Injury Induced by Ischemia/Reperfusion via Regulation of the lncRNA-H19/miR-148a-3p/Rock2 Axis.Oxid Med Cell Longev.2019 Dec 16;2019:8768327.

9.Zhang H#, Lu M, Zhang X, Kuai Y, Mei Y, Tan Q, Zhong K,Sun X*, Tan W*.Isosteviol Sodium Protects against Ischemic Stroke by Modulating Microglia/Macrophage Polarization via Disruption of GAS5/miR-146a-5p sponge.Sci Rep.2019 Aug 21;9(1):12221.

10.Luo Y#, Zeng R#, Guo Q, Xu J,Sun X*, Wang L*.Identifying a novel anticancer agent with microtubule-stabilizing effects through computational cell-based bioactivity prediction models and bioassays.Org. Biomol. Chem.2019, 17, 1519–1530

11.Hao Zhang#,Jie Zan#, Kailun Zhong,Minyi Lu,Xiaoou Sun*, Wen Tan*. Neuroprotective Effects of Isosteviol Sodium through Increasing CYLD by the Downregulation miRNA-181b.Brain Research Bulletin.2018.06, 140:392~401(影响因子:3.44)

12.Hao Zhang#,Xiaoou Sun#,Yanxiang Xie, Fang Tian, Wen Tan*.Isosteviol sodium inhibits astrogliosis after cerebral ischemia/reperfusion injury in rats.Bulletins of the Pharmaceutical Society of Japan.2018Apr;41(4)(影响因子:1.694)

13.Sun X, Yang Y, Xie Y, et al. Protective role of STVNa in myocardial ischemia reperfusion injury by inhibiting mitochondrial fission. Oncotarget. 2017 Dec 5;9(2):1898-1905.(影响因子:5.168)

14.Hao Zhang#,Xiaoou Sun#,Yanxiang Xie, Jie Zhan, Wen Tan*.Isosteviol Sodium Protects Against Permanent Cerebral Ischemia Injury in Mice via Inhibition of NF-κB-Mediated Inflammatory and Apoptotic Responses.Journal of Stroke and Cerebrovascular Diseases.2017 Nov;26(11):2603-2614.(影响因子:1.598)

15.Hao Su#, Marco Pistolozzi, Xingjuan Shi,Xiaoou Sun*, Wen Tan*.Alterations in NO/ROS ratio and expression of Trx1 and Prdx2 in isoproterenol-induced cardiac hypertrophy.Acta Biochim Biophys Sin.2017 Nov 1;49(11):1022-1028.(影响因子:2.224)

16.Xingjuan Shi#*,Xiaoou Sun*.Regulation of paclitaxel activity by microtubule-associated proteins in cancer chemotherapy.Cancer Chemother Pharmacol.2017 Nov;80(5):909-917.

17.Sun X, Shi X, Liu M, Li D, Zhang L, Liu X, Zhou J. Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability.Cell Cycle. 2011 Nov 15; 10(22):3929-37.(影响因子:4.999)

18.Shi X,Sun X(Co-first author), Liu M, Li D, Aneja R, Zhou J. Cep70 interacts with gamma-tubulin to localize at the centrosome and is critical for mitotic spindle assembly.The journal of biological chemistry.2011 Sep 23;286(38):33401-8. Epub 2011 Jul 27.(影响因子:5.328)

19.Sun X, Shi X,Sun X(Co-first author), Luo Y, Wu X, Yao C, Yu H, Li D, Liu M, Zhou J. Dimethylenastron allosterically inhibits the mitotic kinesin Eg5 and suppresses pancreatic cancer cell migration and invasion.Acta Pharmacologica Sinica(2011)32:1543-1548.(影响因子:1.909)

20.Tala,Xiaoou Sun (Co-first author), Jie Chen, Linlin Zhang, Ningning Liu, Jun Zhou, Dengwen Li, Min Liu.Microtubule Stabilization by Mdp3 Is Attributed to Its Modulation of HDAC6 in Addition to Its Association with Tubulin and Microtubules.Plos One2014 Mar 10;9(3):e90932. doi: 10.1371/journal.pone.0090932. eCollection 2014.(影响因子:4.092)

科研项目

1.主持广东省自然科学基金,面上项目:去乙酰化酶Sirtuin家族成员对高脂肪诱导的心脏疾病的调控机制研究

2.主持国家自然科学基金:AEP酶底物Homer蛋白家族在脑缺血再灌注损伤中的作用及分子机制

3.主持广东工业大学青年百人人才项目

4.主持华南理工大学生物科学与工程学院引进人才科研启动费

5.主持华南理工大学中央高校面上项目:“Stv1-Na保护心肌细胞抗缺血再灌注损伤的分子机制”

6.参与973计划:“上皮组织细胞分裂与细胞命运决定”

7.参与973计划:“调控细胞增殖与细胞凋亡的分子机制研究”

8.参与国家自然基金重点项目:“微管结合蛋白EB1磷酸化的调控及功能研究”

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